ArticleHeredity2013
Royal dynasties as human inbreeding laboratories: the Habsburgs.
Article in Heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Ballou's Ancestral Inbreeding Coefficient: Formulation and New Estimate with Higher Reliability.Animals : an open access journal from MDPI · 2024Article
- Measuring the Efficiency of Purging by non-random Mating in Human Populations.Molecular biology and evolution · 2024Article
- Characterizing and Eliminating the Inbreeding Load.Veterinary sciences · 2023Review
- The coefficients of inbreeding revealed by ROH study among inbred individuals belonging to each type of the first cousin marriage: A preliminary report from North India.Genes & genomics · 2023Article
- Mimush Sheep and the Spectre of Inbreeding: Historical Background for Festetics's Organic and Genetic Laws Four Decades Before Mendel's Experiments in Peas.Journal of the history of biology · 2022Article
- Chip Off the Old Block: Generation, Development, and Ancestral Concepts of Heredity.Frontiers in genetics · 2022Review
- Parental relatedness through time revealed by runs of homozygosity in ancient DNA.Nature communications · 2021Article
- The genetic structure of the Turkish population reveals high levels of variation and admixture.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Inbreeding depression for kit survival at birth in a rabbit population under long-term selection.Genetics, selection, evolution : GSE · 2020Article
- Skeletal Anomalies in The Neandertal Family of El Sidrón (Spain) Support A Role of Inbreeding in Neandertal Extinction.Scientific reports · 2019Article
- Detection of genetic purging and predictive value of purging parameters estimated in pedigreed populations.Heredity · 2018Article
- Runs of homozygosity: windows into population history and trait architecture.Nature reviews. Genetics · 2018Review
- Inbreeding estimates in human populations: Applying new approaches to an admixed Brazilian isolate.PloS one · 2018Article
- Ancestry Testing and the Practice of Genetic Counseling.Journal of genetic counseling · 2017Review
- Predictive Model and Software for Inbreeding-Purging Analysis of Pedigreed Populations.G3 (Bethesda, Md.) · 2016Article
- The challenges of pedigree dog health: approaches to combating inherited disease.Canine genetics and epidemiology · 2015Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The European royal dynasties of the Early Modern Age provide a useful framework for human inbreeding research. In this article, consanguineous marriage, inbreeding depression and the purging of deleterious alleles within a consanguineous population are investigated in the Habsburgs, a royal dynasty with a long history of consanguinity over generations. Genealogical information from a number of historical sources was used to compute kinship and inbreeding coefficients for the Habsburgs. The marriages contracted by the Habsburgs from 1450 to 1750 presented an extremely high mean kinship (0.0628±0.009), which was the result of the matrimonial policy conducted by the dynasty to establish political alliances through marriage. A strong inbreeding depression for both infant and child survival was detected in the progeny of 71 Habsburg marriages in the period 1450-1800. The inbreeding load for child survival experienced a pronounced decrease from 3.98±0.87 in the period 1450-1600 to 0.93±0.62 in the period 1600-1800, but temporal changes in the inbreeding depression for infant survival were not detected. Such a reduction of inbreeding depression for child survival in a relatively small number of generations could be caused by elimination of deleterious alleles of a large effect according with predictions from purging models. The differential purging of the infant and child inbreeding loads suggest that the genetic basis of inbreeding depression was probably very different for infant and child survival in the Habsburg lineage. Our findings provide empirical support that human inbreeding depression for some fitness components might be purged by selection within consanguineous populations.
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