ArticleOptics express2013
Can OCT be sensitive to nanoscale structural alterations in biological tissue?
Article in Optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 64 citations in OpenAlex.
- Visible Light Optical Coherence Tomography: Technology and Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Nanosensitive optical coherence tomography for detecting structural changes in stem cells.Biomedical optics express · 2023Article
- Skin cancer margin detection using nanosensitive optical coherence tomography and a comparative study with confocal microscopy.Biomedical optics express · 2022Article
- A pilot and ex-vivo study of examination of endometrium tissue by catheter based optical coherence tomography.BMC medical imaging · 2022Article
- Visible Light Optical Coherence Tomography of Peripapillary Retinal Nerve Fiber Layer Reflectivity in Glaucoma.Translational vision science & technology · 2022Article
- Exploiting Nanomaterials for Optical Coherence Tomography and Photoacoustic Imaging in Nanodentistry.Nanomaterials (Basel, Switzerland) · 2022Review
- Origins of subdiffractional contrast in optical coherence tomography.Biomedical optics express · 2021Article
- Characterization of nanosensitive multifractality in submicron scale tissue morphology and its alteration in tumor progression.Journal of biomedical optics · 2021Article
- Single-cell cytometry via multiplexed fluorescence prediction by label-free reflectance microscopy.Science advances · 2021Article
- Intrinsic spectrally-dependent background in spectroscopic visible-light optical coherence tomography.Biomedical optics express · 2021Article
- Nanosensitive optical coherence tomography to assess wound healing within the cornea.Biomedical optics express · 2020Article
- Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer's Disease in a Mouse Model.Scientific reports · 2020Article
- LED array reflectance microscopy for scattering-based multi-contrast imaging.Optics letters · 2020Article
- High Frequency Spectral Ultrasound Imaging to Detect Metastasis in Implanted Biomaterial Scaffolds.Annals of biomedical engineering · 2020Article
- Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring.Scientific reports · 2019Article
- Longitudinal detection of retinal alterations by visible and near-infrared optical coherence tomography in a dexamethasone-induced ocular hypertension mouse model.Neurophotonics · 2019Article
- Geometry-Dependent Spectroscopic Contrast in Deep Tissues.iScience · 2019Article
- Accurate Monte Carlo simulation of frequency-domain optical coherence tomography.International journal for numerical methods in biomedical engineering · 2019Article
- Quantitative quality-control metrics forBiomedical optics express · 2019Article
- Fully automated fiber-based optical spectroscopy system for use in a clinical setting.Journal of biomedical optics · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Exploration of nanoscale tissue structures is crucial in understanding biological processes. Although novel optical microscopy methods have been developed to probe cellular features beyond the diffraction limit, nanometer-scale quantification remains still inaccessible for in situ tissue. Here we demonstrate that, without actually resolving specific geometrical feature, OCT can be sensitive to tissue structural properties at the nanometer length scale. The statistical mass-density distribution in tissue is quantified by its autocorrelation function modeled by the Whittle-Mateŕn functional family. By measuring the wavelength-dependent backscattering coefficient μb(λ) and the scattering coefficient μs, we introduce a technique called inverse spectroscopic OCT (ISOCT) to quantify the mass-density correlation function. We find that the length scale of sensitivity of ISOCT ranges from ~30 to ~450 nm. Although these sub-diffractional length scales are below the spatial resolution of OCT and therefore not resolvable, they are nonetheless detectable. The sub-diffractional sensitivity is validated by 1) numerical simulations; 2) tissue phantom studies; and 3) ex vivo colon tissue measurements cross-validated by scanning electron microscopy (SEM). Finally, the 3D imaging capability of ISOCT is demonstrated with ex vivo rat buccal and human colon samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.