SynthesisJournal of neural transmission (Vienna, Austria : 1996)2013
Meta-analysis of APOE ε2/ε3/ε4 polymorphism and cerebral infarction.
Synthesis in Journal of neural transmission (Vienna, Austria : 1996), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Apolipoprotein EDisease markers · 2022Pooled it
- Elevated Serum Homocysteine (Hcy) Levels May Contribute to the Pathogenesis of Cerebral Infarction.Journal of molecular neuroscience : MN · 2015Pooled it
- Allopurinol is Associated with an Increased Risk of Cerebral Infarction: A Two-Sample Mendelian Randomization Study.ACS omega · 2024Article
- Apolipoprotein E Gene Polymorphism Effects on Lipid Metabolism and Risk of Cerebral Infarction in Northwest Han Chinese Population.Pharmacogenomics and personalized medicine · 2023Article
- Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke.Scientific reports · 2022Article
- Association of Apolipoprotein E Polymorphisms and Risks of Ischemic Stroke in Chinese Patients with Type 2 Diabetes Mellitus.Journal of diabetes research · 2021Article
- Association of Apolipoprotein E Gene Polymorphism with Lipid Profile and Ischemic Stroke Risk in Type 2 Diabetes Mellitus Patients.Journal of nutrition and metabolism · 2021Article
- The association between the ApoE polymorphisms and the MRI-defined intracranial lesions in a cohort of southern China population.Journal of clinical laboratory analysis · 2019Article
- Rare thrombophilic conditions.Annals of translational medicine · 2018Review
- Association of apolipoprotein E genotype with outcome in hospitalized ischemic stroke patients.Medicine · 2017Article
- Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
- Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population.Cellular & molecular biology letters · 2017Article
- Polymorphisms of apolipoprotein E and aneurysmal subarachnoid haemorrhage: A meta-analysis.Meta gene · 2016Review
- Association between Apolipoprotein ε4 Gene Polymorphism and Risk of Ischemic Stroke: A Meta-Analysis.Annals of neurosciences · 2016Review
- Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population.BMC neurology · 2016Article
- Apolipoprotein E gene E2/E2 genotype is a genetic risk factor for vertebral fractures in humans: a large-scale study.International orthopaedics · 2014Article
- Apolipoprotein E polymorphism is associated with lower extremity deep venous thrombosis: color-flow Doppler ultrasound evaluation.Lipids in health and disease · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk of cerebral infarction (CI) is contributed to the combination of environmental influences and genetic factors. The Apolipoprotein E (APOE) gene polymorphism as a risk factor in CI has been suggested, but direct evidence from genetic association studies remains inconclusive even in Chinese population. The purpose of this study was to identify association between the APOE ε2/ε3/ε4 polymorphism and the development of CI. Published relevant case-control studies were collected from electronic databases. Data were combined using odds ratio (OR) with 95% confidence interval (CI). Totally, 29 studies published from 1997 to 2012, involving 2,737 CI cases and 2,689 controls in Chinese population were subjected to final analysis. The pooled results suggested that CI subjects carrying ε4 allele had an increased risk for CI (ε4 vs. ε3: OR = 2.50, 95% CI 1.98-3.16, P < 0.001, ε4 carriers vs. E3E3 genotype: OR = 2.82, 95% CI 2.16-3.67, P < 0.001), compared with those carrying ε3 allele. However, carriers of APOE ε2 allele had no significant increased risk for CI, compared with those carrying ε3 allele. Potential publication bias was observed in the genetic model of ε4 versus ε3, but the results might not be affected deeply by the publication bias. Using the trim and fill method, the adjusted risk estimate for ε4 allele versus ε3 allele was attenuated but remained significant (OR = 2.00, 95% CI 1.59-2.53, P < 0.001), suggesting the stability of our results. Taken together, our study suggests that APOE ε4 allele is associated with an increased risk of developing CI in Chinese population.
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