ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2013
Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers.
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Who cites it
183 citing papers in PubMed.
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- Oral care tablet containing kiwifruit powder affects tongue coating microbiome.Clinical and experimental dental research · 2022Trial
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- Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 Diabetes.Nutrients · 2021Trial
- Obesity and mental health improvement following nutritional education focusing on gut microbiota composition in Japanese women: a randomised controlled trial.European journal of nutrition · 2019Trial
- Endothelial Function is improved by Inducing Microbial Polyamine Production in the Gut: A Randomized Placebo-Controlled Trial.Nutrients · 2019Trial
- Consumption of a Bifidobacterium bifidum Strain for 4 Weeks Modulates Dominant Intestinal Bacterial Taxa and Fecal Butyrate in Healthy Adults.Applied and environmental microbiology · 2016Trial
- Trial
- Sibling factors associated with gut microbiota and fecal short-chain fatty acids in preschoolers.Pediatric research · 2026Article
- Gut-protective metabolic phenotype for diarrhoeal remission caused by an environmental probiotic thermophile.Microbiome · 2026Article
- Simple endpoint PCR assay using portable devices for Escherichia coli quantification in water samples.Environmental monitoring and assessment · 2026Article
- Changes in gut microbiota composition following water kefir consumption in healthy adults.Scientific reports · 2026Article
- Gut microbiota bidirectionally influences protection and severity in cerebral malaria in mice.Tropical medicine and health · 2026Article
- A Study on the Association Between Treatment Response to Atezolizumab Plus Bevacizumab Combination Therapy for Advanced Hepatocellular Carcinoma and Gut Microbiota.Microorganisms · 2026Article
- Association between bone marrow donor origin and gut microbiota composition following fecal microbiota transplantation in mice.Scientific reports · 2026Article
- Composition and nutritional role of gut microbiota on growth performance of pigs at different growth stages.The British journal of nutrition · 2026Article
- Effect of probioticBioscience of microbiota, food and health · 2026Article
- Development of a monoclonal antibody-based approach for selective enrichment of targetGut microbes reports · 2026Article
123 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Probiotics are live microorganisms that potentially confer beneficial outcomes to host by modulating gut microbiota in the intestine. The aim of this study was to comprehensively investigate effects of probiotics on human intestinal microbiota using 454 pyrosequencing of bacterial 16S ribosomal RNA genes with an improved quantitative accuracy for evaluation of the bacterial composition. We obtained 158 faecal samples from 18 healthy adult Japanese who were subjected to intervention with 6 commercially available probiotics containing either Bifidobacterium or Lactobacillus strains. We then analysed and compared bacterial composition of the faecal samples collected before, during, and after probiotic intervention by Operational taxonomic units (OTUs) and UniFrac distances. The results showed no significant changes in the overall structure of gut microbiota in the samples with and without probiotic administration regardless of groups and types of the probiotics used. We noticed that 32 OTUs (2.7% of all analysed OTUs) assigned to the indigenous species showed a significant increase or decrease of ≥10-fold or a quantity difference in >150 reads on probiotic administration. Such OTUs were found to be individual specific and tend to be unevenly distributed in the subjects. These data, thus, suggest robustness of the gut microbiota composition in healthy adults on probiotic administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.