Evidence map›Paper›PMID 23571587›Full record

SynthesisJAMA2013

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.

Christiane Reitz, Gyungah Jun, Adam Naj, Ruchita Rajbhandary, Badri Narayan Vardarajan, Li-San Wang, Otto Valladares, Chiao-Feng Lin, Eric B Larson, Neill R Graff-Radford and 33 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in JAMA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 267 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
267citing papers in PubMed, 11 pooled it
20.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

267 citing papers in PubMed, 11 syntheses or guidelines pooled it, 454 citations in OpenAlex.

  1. Genetic and environmental risk factors for dementia in African adults: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  18. Black EquaLity in OCD NeuroGenomics (BELONG): Study Protocol.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026
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207 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 1 country.

Christiane ReitzTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University, 630 W 168th St, New York, NY 10032, USA.
Gyungah Jun
Adam Naj
Ruchita Rajbhandary
Badri Narayan Vardarajan
Li-San Wang
Otto Valladares
Chiao-Feng Lin
Eric B Larson
Neill R Graff-Radford
Denis Evans
Philip L De Jager
Paul K Crane
Joseph D Buxbaum
Jill R Murrell
Towfique Raj
Nilufer Ertekin-Taner
Mark Logue
Clinton T Baldwin
Robert C Green
Lisa L Barnes
Laura B Cantwell
M Daniele Fallin
Rodney C P Go
Patrick Griffith
Thomas O Obisesan
Jennifer J Manly
Kathryn L Lunetta
M Ilyas Kamboh
Oscar L Lopez
David A Bennett
Hugh Hendrie
Kathleen S Hall
Alison M Goate
Goldie S Byrd
Walter A Kukull
Tatiana M Foroud
Jonathan L Haines
Lindsay A Farrer
Margaret A Pericak-Vance
Gerard D Schellenberg
Richard Mayeux
Alzheimer Disease Genetics Consortium
University of Pennsylvania · USColumbia University · USRush University · USUniversity of Miami · USHarvard University Press · USIndiana University – Purdue University Indianapolis · USJacksonville College · USUniversity of Pittsburgh · USUniversity of Washington · USBroad Institute · USCalifornia University of Pennsylvania · USGroup Health Cooperative · USHoward University · USIcahn School of Medicine at Mount Sinai · USIndiana University Bloomington · USJohns Hopkins University · USMeharry Medical College · USNorth Carolina Agricultural and Technical State University · USRegenstrief Institute · USUniversity of Alabama at Birmingham · US

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
TRIAL OF VALPROATE TO ATTENUATE THE PROGRESSION OF ADU01AG010483 · NIA · UNIVERSITY OF ROCHESTER · PI AISEN, PAUL S. · 1991 to 2012
$116.2M
RECRUITMENT COREU19AG010483 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDMAN, HOWARD · 2013 to 2020
$80.6M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
NCI NIH HHS R01 CA129769NCI NIH HHS R01CA129769NCI NIH HHS U54 CA132378NCI NIH HHS U54 CA137788NCRR NIH HHS KL2 RR024151NCRR NIH HHS M01 RR000096NCRR NIH HHS MO1RR00096NCRR NIH HHS UL1RR02777NCRR NIH HHS UL1 RR029893NCRR NIH HHS UL1RR029893NHGRI NIH HHS U01 HG004610NHGRI NIH HHS U01 HG006375NIA NIH HHS 5R01AG20688NIA NIH HHS AG005138NIA NIH HHS AG010491NIA NIH HHS AG019757NIA NIH HHS AG021547NIA NIH HHS AG025688NIA NIH HHS AG027944NIA NIH HHS AG030653NIA NIH HHS AG05128NIA NIH HHS K23 AG034550NIA NIH HHS K23AG034550NIA NIH HHS P01 AG002219NIA NIH HHS P01AG002219NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG007232NIA NIH HHS P01 AG010491NIA NIH HHS P01 AG019724NIA NIH HHS P01 AG026276NIA NIH HHS P01 AG03991NIA NIH HHS P30 AG008017NIA NIH HHS P30AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30AG019610NIA NIH HHS P30 AG028377NIA NIH HHS P30AG028377NIA NIH HHS P30 AG028383NIA NIH HHS P30AG028383NIA NIH HHS P30 AG062421NIA NIH HHS P30AG08051NIA NIH HHS P30AG10133NIA NIH HHS P30AG10161NIA NIH HHS P30AG13846NIA NIH HHS P50 AG005128NIA NIH HHS P50 AG005131NIA NIH HHS P50AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008671NIA NIH HHS P50AG008671NIA NIH HHS P50 AG008702NIA NIH HHS P50AG008702NIA NIH HHS P50 AG016570NIA NIH HHS P50AG016570NIA NIH HHS P50 AG016573NIA NIH HHS P50AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50AG016575NIA NIH HHS P50AG016576NIA NIH HHS P50AG016577NIA NIH HHS P50 AG016582NIA NIH HHS P50AG016582NIA NIH HHS P50AG019724NIA NIH HHS P50 AG023501NIA NIH HHS P50AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG05681NIA NIH HHS P50AG16574NIA NIH HHS R01 AG009029NIA NIH HHS R01 AG009956NIA NIH HHS R01AG009956NIA NIH HHS R01 AG011101NIA NIH HHS R01 AG015473NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017173NIA NIH HHS R01AG017173NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019085NIA NIH HHS R01AG019085NIA NIH HHS R01 AG019757NIA NIH HHS R01 AG020688NIA NIH HHS R01 AG021547NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG025259NIA NIH HHS R01AG025259NIA NIH HHS R01 AG026390NIA NIH HHS R01 AG026916NIA NIH HHS R01AG026916NIA NIH HHS R01 AG027944NIA NIH HHS R01 AG028786NIA NIH HHS R01AG028786NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG030653NIA NIH HHS R01 AG031581NIA NIH HHS R01AG031581NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG036040NIA NIH HHS R01 AG037212NIA NIH HHS R01AG037212NIA NIH HHS R01 AG040770NIA NIH HHS R01 AG041797NIA NIH HHS R01 AG1101NIA NIH HHS R01AG15819NIA NIH HHS R01AG17917NIA NIH HHS R01AG22018NIA NIH HHS R01 AG28786-01A1NIA NIH HHS R01AG30146NIA NIH HHS R01AG33193NIA NIH HHS R37 AG015473NIA NIH HHS RC2 AG036528NIA NIH HHS RC2-AG036528NIA NIH HHS RC2 AG036650NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG010483NIA NIH HHS U01 AG016976NIA NIH HHS U01-AG016976NIA NIH HHS U01 AG032984NIA NIH HHS U01-AG032984NIA NIH HHS U01 AG06781NIA NIH HHS U01-AG10483NIA NIH HHS U19 AG010483NIA NIH HHS U24 AG021886NIA NIH HHS U24-AG021886NIA NIH HHS U24 AG026390NIA NIH HHS U24 AG026395NIA NIH HHS U24 AG056270NIMHD NIH HHS P20 MD000546NIMH NIH HHS MH60451NIMH NIH HHS P50 MH060451NIMH NIH HHS R01 MH080295NIMH NIH HHS R01MH080295NINDS NIH HHS NS39764NINDS NIH HHS P50 NS039764NINDS NIH HHS R01 NS036768
6 · The paper itself

Abstract

importanceGenetic variants associated with susceptibility to late-onset Alzheimer disease are known for individuals of European ancestry, but whether the same or different variants account for the genetic risk of Alzheimer disease in African American individuals is unknown. Identification of disease-associated variants helps identify targets for genetic testing, prevention, and treatment.

objectiveTo identify genetic loci associated with late-onset Alzheimer disease in African Americans. DESIGN, SETTING, AND

participantsThe Alzheimer Disease Genetics Consortium (ADGC) assembled multiple data sets representing a total of 5896 African Americans (1968 case participants, 3928 control participants) 60 years or older that were collected between 1989 and 2011 at multiple sites. The association of Alzheimer disease with genotyped and imputed single-nucleotide polymorphisms (SNPs) was assessed in case-control and in family-based data sets. Results from individual data sets were combined to perform an inverse variance-weighted meta-analysis, first with genome-wide analyses and subsequently with gene-based tests for previously reported loci. MAIN OUTCOMES AND MEASURES: Presence of Alzheimer disease according to standardized criteria.

resultsGenome-wide significance in fully adjusted models (sex, age, APOE genotype, population stratification) was observed for a SNP in ABCA7 (rs115550680, allele = G; frequency, 0.09 cases and 0.06 controls; odds ratio [OR], 1.79 [95% CI, 1.47-2.12]; P = 2.2 × 10(-9)), which is in linkage disequilibrium with SNPs previously associated with Alzheimer disease in Europeans (0.8 < D' < 0.9). The effect size for the SNP in ABCA7 was comparable with that of the APOE ϵ4-determining SNP rs429358 (allele = C; frequency, 0.30 cases and 0.18 controls; OR, 2.31 [95% CI, 2.19-2.42]; P = 5.5 × 10(-47)). Several loci previously associated with Alzheimer disease but not reaching significance in genome-wide analyses were replicated in gene-based analyses accounting for linkage disequilibrium between markers and correcting for number of tests performed per gene (CR1, BIN1, EPHA1, CD33; 0.0005 < empirical P < .001). CONCLUSIONS AND RELEVANCE: In this meta-analysis of data from African American participants, Alzheimer disease was significantly associated with variants in ABCA7 and with other genes that have been associated with Alzheimer disease in individuals of European ancestry. Replication and functional validation of this finding is needed before this information is used in clinical settings.

Indexed as

Genome-Wide Association StudyAgedAge of OnsetAlzheimer DiseaseApolipoprotein E4ATP-Binding Cassette TransportersBlack or African AmericanCase-Control StudiesGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansLinkage DisequilibriumMiddle AgedPolymorphism, Single NucleotideRiskABCA7 protein, humanApolipoprotein E4ATP-Binding Cassette Transporters

Identifiers

PMID23571587
PMCPMC3667653
OpenAlexW2003958717

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.