ArticleNeuroImage2013
fMRI in the awake marmoset: somatosensory-evoked responses, functional connectivity, and comparison with propofol anesthesia.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 102 citations in OpenAlex.
- Magnetic Resonance Imaging of Gastric Motility in Conscious Rats.Neurogastroenterology and motility · 2026Article
- Ultrahigh-Field MR-Compatible Mechanical Tactile Stimulator for Investigating Somatosensory Processing in Small-Bodied Animals.NMR in biomedicine · 2025Article
- Fluorescent sensors for intracellular signaling in the brain: imaging neurons, glia, and vascular cells.Neurophotonics · 2025Article
- An open access resource for marmoset neuroscientific apparatus.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Mesoscopic mapping of hemodynamic responses and neuronal activity during pharmacologically induced interictal spikes in awake and anesthetized mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- An anesthetic protocol for preserving functional network structure in the marmoset monkey brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Effect of sedatives or anesthetics on the measurement of resting brain function in common marmosets.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Effects of Anesthesia on Cerebral Blood Flow and Functional Connectivity of Nonhuman Primates.Veterinary sciences · 2022Review
- Fentanyl-induced changes in brain activity in awake nonhuman primates at 9.4 Tesla.Brain imaging and behavior · 2022Article
- Cortical connectivity is embedded in resting state at columnar resolution.Progress in neurobiology · 2022Article
- An open access resource for functional brain connectivity from fully awake marmosets.NeuroImage · 2022Article
- The current status and trend of the functional magnetic resonance combined with stimulation in animals.Frontiers in neuroscience · 2022Article
- Simultaneous functional MRI of two awake marmosets.Nature communications · 2021Article
- Using non-invasive neuroimaging to enhance the care, well-being and experimental outcomes of laboratory non-human primates (monkeys).NeuroImage · 2021Review
- Mesoscopic Mapping of Ictal Neurovascular Coupling in Awake Behaving Mice Using Optical Spectroscopy and Genetically Encoded Calcium Indicators.Frontiers in neuroscience · 2021Article
- Magnetic Resonance Imaging of Marmoset Monkeys.ILAR journal · 2020Review
- Current Topics in Marmoset Anesthesia and Analgesia.ILAR journal · 2020Review
- Altered Resting-State Functional Connectivity Between Awake and Isoflurane Anesthetized Marmosets.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Event-related functional MRI of awake behaving pigeons at 7T.Nature communications · 2020Article
- Twitches, Blinks, and Fidgets: Important Generators of Ongoing Neural Activity.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Functional neuroimaging in animal models is essential for understanding the principles of neurovascular coupling and the physiological basis of fMRI signals that are widely used to study sensory and cognitive processing in the human brain. While hemodynamic responses to sensory stimuli have been characterized in humans, animal studies are able to combine very high resolution imaging with invasive measurements and pharmacological manipulation. To date, most high-resolution studies of neurovascular coupling in small animals have been carried out in anesthetized rodents. Here we report fMRI experiments in conscious, awake common marmosets (Callithrix jacchus), and compare responses to animals anesthetized with propofol. In conscious marmosets, robust BOLD fMRI responses to somatosensory stimulation of the forearm were found in contralateral and ipsilateral regions of the thalamus, primary (SI) and secondary (SII) somatosensory cortex, and the caudate nucleus. These responses were markedly stronger than those in anesthetized marmosets and showed a monotonic increase in the amplitude of the BOLD response with stimulus frequency. On the other hand, anesthesia significantly attenuated responses in thalamus, SI and SII, and abolished responses in caudate and ipsilateral SI. Moreover, anesthesia influenced several other aspects of the fMRI responses, including the shape of the hemodynamic response function and the interareal (SI-SII) spontaneous functional connectivity. Together, these findings demonstrate the value of the conscious, awake marmoset model for studying physiological responses in the somatosensory pathway, in the absence of anesthesia, so that the data can be compared most directly to fMRI in conscious humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.