ArticleScientific reports2013
Intra-specific diversity of Serratia marcescens in Anopheles mosquito midgut defines Plasmodium transmission capacity.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.
- Fungal microbiota diversity inWellcome open research · 2026Pooled it
- Mosquito-based malaria control through genetic, microbial and immunological innovations.Nature reviews. Microbiology · 2026Review
- Bacterial and Fungal Microbiota in Anopheles darlingi Exhibit Differences in Diversity Across Three Main Colombian Malaria-endemic Regions.Microbial ecology · 2026Article
- Convergent enrichment of Gammaproteobacteria along Aedes aegypti development across different breeding sites.Animal microbiome · 2026Article
- Serratia marcescens and Enterobacter cloacae exhibit differential population dynamics in Anopheles gambiae s.l after sugar and blood feeding.Malaria journal · 2026Article
- Microbiota diversity ofmSphere · 2025Article
- Molecular characterization of potential Plasmodium-Blocking Serratia spp. bacteria in field-caught malaria mosquito in Burkina Faso.Parasites & vectors · 2025Article
- Influence of the Origin, Feeding Status, andBiology · 2025Article
- Leveraging microbial ecology for mosquito-borne disease control.Trends in parasitology · 2025Review
- Emerging challenges for mosquito-borne disease control and the promise of symbiont-based transmission-blocking strategies.PLoS pathogens · 2025Review
- Symbiotic Bacteria: Wolbachia, Midgut Microbiota in Mosquitoes and Their Importance for Vector Prevention Strategies.Microbial ecology · 2024Review
- Two promising candidates for paratransgenesis, Elizabethkingia and Asaia, increase in both sexes of Anopheles gambiae mosquitoes after feeding.Malaria journal · 2024Article
- Biotechnological Potential of Microorganisms for Mosquito Population Control and Reduction in Vector Competence.Insects · 2023Review
- Holobiont perspectives on tripartite interactions among microbiota, mosquitoes, and pathogens.The ISME journal · 2023Review
- Microbiota perturbation by anti-microbiota vaccine reduces the colonization of Borrelia afzelii in Ixodes ricinus.Microbiome · 2023Article
- Bacterial Microbiota from Lab-Reared and Field-CapturedMicroorganisms · 2023Article
- Article
- A rare sugar, allose, inhibits the development ofFrontiers in cellular and infection microbiology · 2023Article
- Anopheline mosquito saliva contains bacteria that are transferred to a mammalian host through blood feeding.Frontiers in microbiology · 2023Article
- Identification of Bacterial Communities and Tick-Borne Pathogens inTropical medicine and infectious disease · 2022Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A critical stage in malaria transmission occurs in the Anopheles mosquito midgut, when the malaria parasite, Plasmodium, ingested with blood, first makes contact with the gut epithelial surface. To understand the response mechanisms within the midgut environment, including those influenced by resident microbiota against Plasmodium, we focus on a midgut bacteria species' intra-specific variation that confers diversity to the mosquito's competency for malaria transmission. Serratia marcescens isolated from either laboratory-reared mosquitoes or wild populations in Burkina Faso shows great phenotypic variation in its cellular and structural features. Importantly, this variation is directly correlated with its ability to inhibit Plasmodium development within the mosquito midgut. Furthermore, this anti-Plasmodium function conferred by Serratia marcescens requires increased expression of the flagellum biosynthetic pathway that is modulated by the motility master regulatory operon, flhDC. These findings point to new strategies for controlling malaria through genetic manipulation of midgut bacteria within the mosquito.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.