Trial reportIndian journal of ophthalmology2013
Comparison of outcomes of trabeculectomy with mitomycin C vs. ologen implant in primary glaucoma.
Trial report in Indian journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Device-modified trabeculectomy for glaucoma.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Device-modified trabeculectomy for glaucoma.The Cochrane database of systematic reviews · 2015Pooled it
- Ologen implant versus mitomycin C for trabeculectomy: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Collagen matrix vs mitomycin-C in trabeculectomy and combined phacoemulsification and trabeculectomy: a randomized controlled trial.BMC ophthalmology · 2016Trial
- Biodegradable collagen matrix implant versus mitomycin-C in trabeculectomy: five-year follow-up.BMC ophthalmology · 2016Trial
- Management and outcomes of primary open-angle glaucoma.Journal of family medicine and primary care · 2026Review
- Comparison between modified and conventional combined Trabeculotomy-Trabeculectomy with Mitomycin-C for intraocular pressure reduction in primary congenital glaucoma.Pakistan journal of medical sciences · 2024Article
- Comparison of surgical outcomes with and without Ologen collagen matrix augmentation during XEN gel stent implantation.BMC ophthalmology · 2022Article
- Trabeculectomy: Does It Have a Future?Cureus · 2022Review
- Ologen implant versus mitomycin C in combined trabeculectomy and phacoemulsification.Indian journal of ophthalmology · 2022Article
- Comparison of bleb morphology by anterior segment optical coherence tomography and clinical outcome after phacotrabeculectomy with mitomycin C or Ologen implant.Indian journal of ophthalmology · 2021Article
- Aurolab aqueous drainage implant in the vitreous cavity: Our modifications over the conventional technique of glaucoma implant surgery.Indian journal of ophthalmology · 2021Article
- Cross-linked hyaluronic acid viscoelastic scleral implant in trabeculectomy.Indian journal of ophthalmology · 2021Article
- Trabeculectomy in pregnancy: Case studies and literature review.Indian journal of ophthalmology · 2020Review
- Non-Penetrating Deep Sclerectomy versus Trabeculectomy in Primary Congenital Glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Trabeculectomy with subconjunctival collagen implant in Indian eyes: Long-term results.Indian journal of ophthalmology · 2018Article
- Five Years' Outcomes of Trabeculectomy with Cross-linked Sodium Hyaluronate Gel Implantation for Chinese Glaucoma Patients.Chinese medical journal · 2018Article
- A Comparative Study: The Use of Collagen Implant versus Mitomycin-C in Combined Trabeculotomy and Trabeculectomy for Treatment of Primary Congenital Glaucoma.Journal of ophthalmology · 2017Article
- Trabeculectomy with ologen in secondary glaucomas following failed trabeculectomy with MMC: comparative study.Eye (London, England) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the safety and efficacy of trabeculectomy with Ologen implant vs. trabeculectomy with Mitomycin C (MMC). MATERIALS AND
methodsIn a prospective, randomized, pilot study, 39 eyes of 33 subjects with medically uncontrolled primary glaucoma, aged 18 years or above underwent trabeculectomy either with MMC (20 eyes) or with Ologen implant (19 eyes). The primary outcome measure was cumulative success probability, defined as complete if the intraocular pressure (IOP) was > 5 and ≤ 21 mm Hg without anti-glaucoma medications or additional surgery and qualified if an IOP was > 5 and ≤ 21 mm Hg with or without anti-glaucoma medications.
resultsMean (± standard deviation) follow-up in Ologen group was 19.1 ± 8.1 months, and in MMC group was 18.0 ± 8.4 months. Mean IOP reduction at 6 months was significantly lower (P = 0.01) in the MMC group (11.9 ± 2.9 mm Hg) as compared to Ologen group (14.6 ± 2.7 mm Hg). However, at 12 months (P = 0.81) and 24 months (P = 0.32), the mean IOP was similar between the 2 groups. Complete success probability at the end of 6 months in Ologen group was 100% (95% confidence interval: 59.1 - 99.0) was similar (P = 0.53) to that in MMC group (93.8%, 95% CI: 63.2 - 99.1). The incidences of early post-operative complications were similar in the 2 groups, except hyphema, which was significantly more in Ologen group (P = 0.02).
conclusionIn this pilot study, the success of trabeculectomy and complications were similar in both Ologen and MMC groups at the end of 6 months.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.