ArticleDevelopment (Cambridge, England)2013
An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells.FEBS open bio · 2026Article
- Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate.Nature communications · 2024Article
- Article
- Cis-inhibition suppresses basal Notch signaling during sensory organ precursor selection.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers.PLoS computational biology · 2023Article
- The Notch signaling pathway in skeletal muscle health and disease.Muscle & nerve · 2022Review
- Article
- Article
- Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling.Nature communications · 2018Article
- Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands.Journal of visualized experiments : JoVE · 2018Article
- Notch signaling triggers the tumor heterogeneity of small cell lung cancer.Journal of thoracic disease · 2017Article
- Article
- Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila.PLoS genetics · 2017Article
- Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning.Developmental cell · 2017Article
- Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation.PloS one · 2017Article
- Transmission of survival signals through Delta-like 1 on activated CD4Scientific reports · 2016Article
- Notch-Mediated Cell Adhesion.Biology · 2016Review
- Ligand-Independent Mechanisms of Notch Activity.Trends in cell biology · 2015Review
- Ligand-Mediated cis-Inhibition of Receptor Signaling in the Self-Incompatibility Response of the Brassicaceae.Plant physiology · 2015Article
- Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.PLoS genetics · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Cell-to-cell communication via the Notch pathway is mediated between the membrane-bound Notch receptor and either of its canonical membrane-bound ligands Delta or Serrate. Notch ligands mediate receptor transactivation between cells and also mediate receptor cis-inhibition when Notch and ligand are co-expressed on the same cell. We demonstrate in Drosophila that removal of any of the EGF-like repeats (ELRs) 4, 5 or 6 results in a Serrate molecule capable of transactivating Notch but exhibiting little or no Notch cis-inhibition capacity. These forms of Serrate require Epsin (Liquid facets) to transduce a signal, suggesting that ELR 4-6-deficient ligands still require endocytosis for Notch activation. We also demonstrate that ELRs 4-6 are responsible for the dominant-negative effects of Serrate ligand forms that lack the intracellular domain and are therefore incapable of endocytosis in the ligand-expressing cell. We find that ELRs 4-6 of Serrate are conserved across species but do not appear to be conserved in Delta homologs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.