ArticleHuman vaccines & immunotherapeutics2013
Age is an important determinant in humoral and T cell responses to immunization with hepatitis B surface antigen.
Article in Human vaccines & immunotherapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04540653 (Immunogenicity of the Hepatitis B Vaccine in Individuals 50 Years Old or More), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immunogenicity of the Hepatitis B Vaccine in Individuals 50 Years Old or More: Randomized Clinical Trial
Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Immunogenicity persistence after four intramuscular triple-dose or standard-dose hepatitis B vaccine in patients receiving methadone maintenance treatment: A 1-year follow-up study in China.Human vaccines & immunotherapeutics · 2025Trial
- Low Immunogenicity of Recombinant Hepatitis B Vaccine Derived from Hansenula polymorpha in Adults Aged Over 40 Years.The American journal of tropical medicine and hygiene · 2017Trial
- Article
- National trends in acute viral hepatitis in China from 1990-2023: An analysis of the Global Burden of Disease 2023 update.Chinese medical journal · 2026Article
- Role of cellular senescence in hepatic diseases (Review).International journal of molecular medicine · 2025Review
- Restoring Trust: The Need for Precision Medicine in Infectious Diseases, Public Health and Vaccines.Human vaccines & immunotherapeutics · 2023Review
- Severely ill and high-risk COVID-19 patients exhibit increased peripheral circulation of CD62L+ and perforin+ T cells.Frontiers in immunology · 2023Article
- Observational
- Article
- Food Allergies and Ageing.International journal of molecular sciences · 2019Review
- Long-term persistency of hepatitis B immunity: an observational cross-sectional study on medical students and resident doctors.Journal of preventive medicine and hygiene · 2019Observational
- Management Approaches to Hepatitis B Virus Vaccination Nonresponse.Gastroenterology & hepatology · 2019Article
- Next-generation sequencing analysis of the human T-cell and B-cell receptor repertoire diversity before and after hepatitis B vaccination.Human vaccines & immunotherapeutics · 2019Article
- A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018Article
- The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span.GeroScience · 2018Review
- Is hepatitis B vaccination performed at infant and adolescent age able to provide long-term immunological memory? An observational study on healthcare students and workers in Florence, Italy.Human vaccines & immunotherapeutics · 2018Observational
- The Human Vaccines Project: Towards a comprehensive understanding of the human immune response to immunization.Human vaccines & immunotherapeutics · 2018Review
- Influence of Aging and Environment on Presentation of Infection in Older Adults.Infectious disease clinics of North America · 2017Review
- Persistence of protective anti-HBs antibody levels and anamnestic response to HBV booster vaccination: A cross-sectional study among healthcare students 20 years following the universal immunization campaign in Italy.Human vaccines & immunotherapeutics · 2017Observational
- Immunosenescence in aging: between immune cells depletion and cytokines up-regulation.Clinical and molecular allergy : CMA · 2017Review
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aging of the immune system, also named immunosenescence, affects vaccine responses. However, the onset of age-related immunosenescence has been uncertain, in particularly with regard to vaccine responses. Here, we show that the formation of antibodies in response to vaccination against hepatitis B virus infection was significantly reduced for donors with a mean age of 61 y compared with a group with a mean age of 33 y. Booster vaccination sero-converted the elderly donors, but only at a reduced level, while a stronger response was found for the group of young donors. Agreeing with these findings, the hepatitis B surface antigen-specific proliferative responses by donor-derived T cells were reduced for the elder donors. Interestingly, the association between expression of the adhesion molecule CD62L (L-selectin) on naïve and central memory T cells and the formation of antigen-specific antibodies differed significantly between younger and elder donors. This finding corresponds well with the observation made previously that CD62L gene ablation in animals alters the formation of antigen-specific antibodies. We suggest that a complex interplay between the expression of CD62L and its ligands is a determinant in early-age immunosenescence affecting the response to HBV vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.