ReviewCurrent opinion in neurobiology2013
A circadian clock nanomachine that runs without transcription or translation.
Review in Current opinion in neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Ultradian rhythms of AKT phosphorylation and gene expression emerge in the absence of the circadian clock components Per1 and Per2.PLoS biology · 2021Article
- Molecular Interactions between Pathogens and the Circadian Clock.International journal of molecular sciences · 2019Review
- Circadian biology and sleep in monogenic neurological disorders and its potential application in drug discovery.Current opinion in behavioral sciences · 2019Article
- Revealing circadian mechanisms of integration and resilience by visualizing clock proteins working in real time.Nature communications · 2018Article
- Article
- Timing the day: what makes bacterial clocks tick?Nature reviews. Microbiology · 2017Review
- Architecture and mechanism of the central gear in an ancient molecular timer.Journal of the Royal Society, Interface · 2017Review
- Expression and Purification of Cyanobacterial Circadian Clock Protein KaiC and Determination of Its Auto-phosphatase Activity.Bio-protocol · 2017Article
- A dynamic interaction process between KaiA and KaiC is critical to the cyanobacterial circadian oscillator.Scientific reports · 2016Article
- Evolution of KaiC-Dependent Timekeepers: A Proto-circadian Timing Mechanism Confers Adaptive Fitness in the Purple Bacterium Rhodopseudomonas palustris.PLoS genetics · 2016Article
- Diversity and Evolution of Type IV pili Systems in Archaea.Frontiers in microbiology · 2016Article
- Circadian Clocks: Unexpected Biochemical Cogs.Current biology : CB · 2015Article
- Biochemistry that times the day.Biochemistry · 2015Article
- Intricate protein-protein interactions in the cyanobacterial circadian clock.The Journal of biological chemistry · 2014Review
- An arginine tetrad as mediator of input-dependent and input-independent ATPases in the clock protein KaiC.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Metabolic compensation and circadian resilience in prokaryotic cyanobacteria.Annual review of biochemistry · 2014Review
- CryoEM and molecular dynamics of the circadian KaiB-KaiC complex indicates that KaiB monomers interact with KaiC and block ATP binding clefts.Journal of molecular biology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The biochemical basis of circadian timekeeping is best characterized in cyanobacteria. The structures of its key molecular players, KaiA, KaiB, and KaiC are known and these proteins can reconstitute a remarkable circadian oscillation in a test tube. KaiC is rhythmically phosphorylated and its phospho-status is a marker of circadian phase that regulates ATPase activity and the oscillating assembly of a nanomachine. Analyses of the nanomachines have revealed how their timing circuit is ratcheted to be unidirectional and how they stay in synch to ensure a robust oscillator. These insights are likely to elucidate circadian timekeeping in higher organisms, including how transcription and translation could appear to be a core circadian timer when the true pacemaker is an embedded biochemical oscillator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.