ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2013
Short-term recognition memory correlates with regional CNS expression of microRNA-138 in mice.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- microRNA and the Post-Transcriptional Response to Oxidative Stress during Neuronal Differentiation: Implications for Neurodevelopmental and Psychiatric Disorders.Life (Basel, Switzerland) · 2024Article
- MiR-138-5p Upregulation during Neuronal Maturation Parallels with an Increase in Neuronal Survival.International journal of molecular sciences · 2023Article
- Roles of Non-Coding RNA in Alzheimer's Disease Pathophysiology.International journal of molecular sciences · 2023Review
- Functions of Circular RNA in Human Diseases and Illnesses.Non-coding RNA · 2023Review
- MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord.Biomedicines · 2022Article
- Article
- Ghrelin Acylation-A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis.Cells · 2022Review
- RETRACTED: circTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene, Tulp4Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- Whole-Transcriptome Analysis of APP/PS1 Mouse Brain and Identification of circRNA-miRNA-mRNA Networks to Investigate AD Pathogenesis.Molecular therapy. Nucleic acids · 2019Article
- Pivotal role of microRNA-138 in human cancers.American journal of cancer research · 2019Review
- A Synthetic Plasmid Toolkit forFrontiers in microbiology · 2019Article
- Roles of Circular RNAs in Neurologic Disease.Frontiers in molecular neuroscience · 2016Review
- Role of MicroRNA in Governing Synaptic Plasticity.Neural plasticity · 2016Review
- A plate-based electrochromic approach for the high-throughput detection of electrochemically active bacteria.Nature protocols · 2014Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe hypothesized that microRNA (miR) expression may be involved in memory function because it controls local protein translation at synapses and dendritic spines.
designCase-control animal study.
methodsWe assessed the miR repertoire in the hippocampus of young, 6-month-old (N = 18) mice compared with aged, 26-month-old (N = 23) mice and compared miR quantity to memory scores as determined by the novel object recognition task. We performed a histological brain regional analysis of miR-138, acyl protein thioesterase 1 (APT1) mRNA, and APT1 protein.
resultsWe found that higher miR-138 expression in the mouse hippocampus is correlated with better memory performance. We also found that APT1 (a depalmytoylation enzyme expressed at dendritic spines whose translation is controlled by miR-138) mRNA is increased in the mouse hippocampal CA1 and dentate gyrus in aged mice compared with young mice, but not in mice with memory impairment. We found APT1 protein distribution to be lower in cells with high miR-138 expression.
conclusionsThese results suggest that increased miR-138 is associated with better memory and increased APT1 gene transcription occurs with aging. The role of miR-138 and APT1 protein function in memory and aging warrants further investigation.
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