ArticleComparative biochemistry and physiology. Toxicology & pharmacology : CBP2013
Chronic vitamin E deficiency promotes vitamin C deficiency in zebrafish leading to degenerative myopathy and impaired swimming behavior.
Article in Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Deciphering the enigma of the function of alpha-tocopherol as a vitamin.Free radical biology & medicine · 2024Article
- Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment.bioRxiv : the preprint server for biology · 2024Article
- Chronic Vitamin E Deficiency Dysregulates Purine, Phospholipid, and Amino Acid Metabolism in Aging Zebrafish Skeletal Muscle.Antioxidants (Basel, Switzerland) · 2023Article
- Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio).The Journal of nutritional biochemistry · 2021Article
- Possible Biochemical Processes Underlying the Positive Health Effects of Plant-Based Diets-A Narrative Review.Nutrients · 2021Review
- RedEfish: Generation of the Polycistronic mScarlet: GSG-T2A: Ttpa Zebrafish Line.Antioxidants (Basel, Switzerland) · 2021Article
- Vitamin E Deficiency Disrupts Gene Expression Networks during Zebrafish Development.Nutrients · 2021Article
- Ccn6 Is Required for Mitochondrial Integrity and Skeletal Muscle Function in Zebrafish.Frontiers in cell and developmental biology · 2021Article
- High-resolution polarization-sensitive optical coherence tomography for zebrafish muscle imaging.Biomedical optics express · 2020Article
- Influence of Commercial and Laboratory Diets on Growth, Body Composition, and Reproduction in the ZebrafishZebrafish · 2019Article
- Chronic vitamin E deficiency impairs cognitive function in adult zebrafish via dysregulation of brain lipids and energy metabolism.Free radical biology & medicine · 2017Article
- Lethal dysregulation of energy metabolism during embryonic vitamin E deficiency.Free radical biology & medicine · 2017Article
- "Muscling" Throughout Life: Integrating Studies of Muscle Development, Homeostasis, and Disease in Zebrafish.Current topics in developmental biology · 2017Review
- Article
- The antioxidant requirement for plasma membrane repair in skeletal muscle.Free radical biology & medicine · 2015Article
- Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics.Journal of lipid research · 2015Article
- Proteome-driven elucidation of adaptive responses to combined vitamin E and C deficiency in zebrafish.Journal of proteome research · 2014Article
- Interactions between α-tocopherol, polyunsaturated fatty acids, and lipoxygenases during embryogenesis.Free radical biology & medicine · 2014Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We hypothesized that zebrafish (Danio rerio) undergoing long-term vitamin E deficiency with marginal vitamin C status would develop myopathy resulting in impaired swimming. Zebrafish were fed for 1 y a defined diet without (E-) and with (E+) vitamin E (500 mg α-tocopherol/kg diet). For the last 150 days, dietary ascorbic acid concentrations were decreased from 3500 to 50 mg/kg diet and the fish sampled periodically to assess ascorbic acid concentrations. The ascorbic acid depletion curves were faster in the E- compared with E+ fish (P < 0.0001); the estimated half-life of depletion in the E- fish was 34 days, while in it was 55 days in the E+ fish. To assess swimming behavior, zebrafish were monitored individually following a "startle-response" stimulus, using computer and video technology. Muscle histopathology was assessed using hematoxylin and eosin staining on paramedian sections of fixed zebrafish. At study end, E- fish contained 300-fold less α-tocopherol (p < 0.0001), half the ascorbic acid (p = 0.0001) and 3-fold more malondialdehyde (p = 0.0005) than did E+ fish. During the first minute following a tap stimulus (p < 0.05), E+ fish swam twice as far as did E- fish. In the E- fish, the sluggish behavior was associated with a multifocal, polyphasic, degenerative myopathy of the skeletal muscle. The myopathy severity ranged from scattered acute necrosis to widespread fibrosis and was accompanied by increased anti-hydroxynonenal staining. Thus, vitamin E deficiency in zebrafish causes increased oxidative stress and a secondary depletion of ascorbic acid, resulting in severe damage to muscle tissue and impaired muscle function.
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