ArticleAsian Pacific journal of tropical biomedicine2012
Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study.
Article in Asian Pacific journal of tropical biomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Morin, as a natural flavonoid, provides promising influences against cardiovascular diseases.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Network pharmacology, molecular docking, and In Vitro evaluation of morin against gastric cancer.Molecular diversity · 2026Article
- Article
- Flavonoids in Treatment of Chronic Kidney Disease.Molecules (Basel, Switzerland) · 2022Review
- Ameliorative effect of biosynthesized titanium dioxide nanoparticles using garlic extract on the body weight and developmental toxicity of liver in albino rats compared with chemically synthesized nanoparticles.Frontiers in veterinary science · 2022Article
- Antihypertensive Effects of theEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Effect of Aqueous Extract ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Inhibitory Effect of Morin AgainstFrontiers in microbiology · 2020Article
- Antihypertensive Effect of Ethanolic Extract fromOxidative medicine and cellular longevity · 2018Article
- Flavonoids in Kidney Health and Disease.Frontiers in physiology · 2018Review
- Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.World journal of gastroenterology · 2017Article
- Identification of morin as an agonist of imidazoline I-3 receptor for insulin secretion in diabetic rats.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats.International journal of ophthalmology · 2016Article
- The effect of ozone on blood pressure in DOCA-salt-induced hypertensive rats.International journal of clinical and experimental medicine · 2015Article
- The flavonoid morin restores blood pressure and lipid metabolism in DOCA-salt hypertensive rats.Redox report : communications in free radical research · 2012Article
- Antihypertensive and antioxidant effects of a hydroalcoholic extract obtained from aerial parts of Otostegia persica (Burm.) Boiss.Research in pharmaceutical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the protective effect of morin, a flavonoid against deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats.
methodsHypertension was induced in uninephrectomized rats by weekly twice subcutaneous injection of DOCA (25 mg/kg bw) and 1% NaCl in the drinking water for six consecutive weeks. Effect of morin against DOCA-salt induced hypertension was evaluated by measuring blood pressure and performing biochemical estimations and histopathological examination of renal tissues.
resultsDOCA-salt hypertensive rats showed considerably increased systolic and diastolic blood pressure, serum hepatic marker enzyme activities such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT) and renal function markers (urea, uric acid and creatinine) in plasma. Oral administration of morin (25, 50 and 75 mg/kg bw) brought back all the above parameters to near normal level. Histopathology of kidney also confirmed the biochemical findings of this study. The effect at a dose of 50 mg/kg bw of morin was more pronounced than that of the other two doses (25 and 75 mg/kg bw).
conclusionsThese findings indicate that morin exhibits strong antihypertensive effect against DOCA-salt induced hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.