ArticleAsian Pacific journal of tropical biomedicine2012
Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis.
Article in Asian Pacific journal of tropical biomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Exploring the antimalarial potential of (+)-2,2'-epicytoskyrin A: in vitro and in vivo studies of a bioactive metabolite from endophytic fungus Diaporthe sp. GNBP-10.Malaria journal · 2026Article
- Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha.Frontiers in oncology · 2022Review
- Oral Administration of Piperine as Curative and Prophylaxis Reduces Parasitaemia inJournal of tropical medicine · 2022Article
- Piperine Enhances the Antimalarial Activity of Curcumin inEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Evaluation of the effect of probiotic as add-on therapy with conventional therapy and alone in malaria induced mice.BMC research notes · 2021Article
- Application of quinoline derivatives in third-generation photovoltaics.Journal of materials science. Materials in electronics · 2021Review
- Article
- Hydroxychloroquine in COVID-19: Potential Mechanism of Action Against SARS-CoV-2.Current pharmacology reports · 2020Review
- Traditional Herbal Medicine Candidates as Complementary Treatments for COVID-19: A Review of Their Mechanisms, Pros and Cons.Evidence-based complementary and alternative medicine : eCAM · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effects of quinine and chloroquine against male mice infected with Plasmodium berghei and their adverse effects on the mice testes.
methodsIn this study, 48 adult male mice, (20-25 g), aged 8 to 12 weeks were divided into four groups. This study was carried out from December 2009 until May 2010 in the School of Public Health, Tehran University of Medical Sciences.
resultsThe results showed that 58.33% of mice treated with chloroquine were completely recovered. Parasitemia was 4% on day 8 when compared to that on day 0, whereas it was 9% on day 9. There was no orchitis found in this group. The mortality of mice after exposing to quinine on day 5 was 8.3%, whereas from day 10 to day 14 it was 91.7%. We found 75% orchitis occurred in quinine treated group. There was a significant difference between quinine and chloroquine effects on the parasite and also mice testes (P<0.05).
conclusionsIn this study, It can be concluded that male mice have full resistance to the quinine. Quinine does not only make male mice recover completely, but also cause inflammation on mice testicles tissue.
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