ArticleAsian Pacific journal of tropical biomedicine2012
Screening of flavonoid "quercetin" from the rhizome of Smilax china Linn. for anti-psoriatic activity.
Article in Asian Pacific journal of tropical biomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 92 citations in OpenAlex.
- Article
- The Influence of Phytoconstituents for the Management of Antipsoriatic Activity in Various Animal Models.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2024Review
- Therapeutic potential of Smilax fluminensis ethanolic extract: antitumoral activity in murine melanoma cells.Molecular and cellular biochemistry · 2022Article
- Flavonoids Present in Propolis in the Battle against Photoaging and Psoriasis.Antioxidants (Basel, Switzerland) · 2021Review
- Polymeric Gels and Their Application in the Treatment of Psoriasis Vulgaris: A Review.International journal of molecular sciences · 2021Review
- GC-MS analysis of the methanolic extracts ofTurkish journal of chemistry · 2020Article
- Homocysteine and psoriasis.Bioscience reports · 2019Review
- Exploration of Phyllanthus acidus mediated silver nanoparticles and its activity against infectious bacterial pathogen.Chemistry Central journal · 2018Article
- Chronic diseases, inflammation, and spices: how are they linked?Journal of translational medicine · 2018Review
- Antipsoriatic Effects of Wannachawee Recipe on Imiquimod-Induced Psoriasis-Like Dermatitis in BALB/c Mice.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Healing effect of Dillenia indica fruit extracts standardized to betulinic acid on ultraviolet radiation-induced psoriasis-like wounds in rats.Pharmaceutical biology · 2017Article
- Effects of Wannachawee Recipe with Antipsoriatic Activity on Suppressing Inflammatory Cytokine Production in HaCaT Human Keratinocytes.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Assessment of Anti-TNF-α Activities in Keratinocytes Expressing Inducible TNF- α: A Novel Tool for Anti-TNF-α Drug Screening.PloS one · 2016Article
- Anti-psoriatic activity of Givotia rottleriformis in rats.Indian journal of pharmacologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess anti-psoriatic activity of the methanol extract and the isolated flavonoid quercetin from the rhizome of Smilax china (S. china) Linn.
methodsMouse tail test was used for the evaluation of anti-psoriatic activity. Methanol extract (100 and 200 mg/kg b.w.) and isolated flavonoid quercetin (25 and 50 mg/kg b.w.) were tested in Swiss albino mice. Parameters studied in the mouse tail test were changes in epidermal thickness and percentage orthokeratotic values. The anti-inflammatory role of the methanol extract and isolated flavonoid quercetin was evaluated using carrageenan-induced pleurisy in rats. In vitro antiproliferant assay on HaCaT cell lines was also carried out.
resultsThe isolated flavonoid quercetin from the rhizome of S. china produced significant orthokeratosis (P<0.01) in the mouse tail test. In epidermal thickness, a significant reduction with respect to control was observed in groups treated with retinoic acid and isolated flavonoid quercetin. The methanol extract (200 mg/kg) and isolated flavonoid quercetin (50 mg/kg) showed anti-inflammatory effect in terms of significant inhibition (P<0.001) in leukocyte migration. Maximum antiproliferant activity was shown by isolated flavonoid quercetin (IC50, 62.42±10.20 µg/mL).
conclusionsFrom the above data, the flavonoid quercetin shows significant orthokeratosis, anti-inflammatory and maximum antiproliferant activities. To our knowledge, this is the first report on the anti-psoriatic effect of the flavonoid quercetin which is promising for further investigations to prove its anti-psoriatic activity.
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