Evidence map›Paper›PMID 23569887›Full record

ArticleAsian Pacific journal of tropical biomedicine2012

Larvicidal and irritant activities of hexane leaf extracts of Citrus sinensis against dengue vector Aedes aegypti L.

Radhika Warikoo, Ankita Ray, Jasdeep Kaur Sandhu, Roopa Samal, Naim Wahab, Sarita Kumar

Open access · greenAbstract read
In one paragraph

Article in Asian Pacific journal of tropical biomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 58 citations in OpenAlex.

  1. Larvicide activity of yeast-encapsulated orange oil againstCurrent research in parasitology & vector-borne diseases · 2025
    Article
  2. Metabolic detoxification andFrontiers in physiology · 2022
    Article
  3. Target and non-target effects ofSaudi journal of biological sciences · 2021
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Larvicidal and Enzymatic Inhibition Effects ofPharmaceuticals (Basel, Switzerland) · 2019
    Article
  9. Larvicidal activity ofJournal of experimental pharmacology · 2019
    Article
  10. Bio-Pesticides: New Tool for the Control ofJournal of arthropod-borne diseases · 2017
    Article
  11. Article
  12. Chemistry and Pharmacology of Citrus sinensis.Molecules (Basel, Switzerland) · 2016
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Radhika WarikooDepartment of Zoology, Acharya Narendra Dev College, University of Delhi, New Delhi-110019, India.
Ankita Ray
Jasdeep Kaur Sandhu
Roopa Samal
Naim Wahab
Sarita Kumar
University of Delhi · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the larvicidal and irritant activities of the hexane extracts of leaves of Citrus sinensis (C. sinensis) against the early fourth instars and female adults of Aedes aegypti (Ae. aegypti).

methodsThe larvicidal potential of the prepared leaf extract was evaluated against early fourth instar larvae of Ae. aegypti using WHO protocol. The mortality counts were made after 24 h and LC50 and LC90 values were calculated. The efficacy of extract as mosquito irritant was assessed by contact irritancy assays. Extract-impregnated paper was placed on a glass plate over which a perspex funnel with a hole on the top was kept inverted. Single female adult, 3-day old unfed/blood-fed, was released inside the funnel. After 3 min of acclimatization time, the time taken for the first take-off and total number of flights undertaken during 15 min were scored.

resultsThe citrus leaf extracts from hexane possessed moderate larvicidal efficiency against dengue vector. The bioassays resulted in an LC50 and LC90 value of 446.84 and 1 370.96 ppm, respectively after 24 h of exposure. However, the extracts were proved to be remarkable irritant against adults Ae. aegypti, more pronounced effects being observed on blood-fed females than unfed females. The extract-impregnated paper was thus proved to be 7-11 times more irritable as compared with the control paper.

conclusionsThe hexane extracts from C. sinensis leaves are proved to be reasonably larvicidal but remarkably irritant against dengue vector. Further studies are needed to identify the possible role of extract as adulticide, oviposition deterrent and ovicidal agent. The isolation of active ingredient from the extract could help in formulating strategies for mosquito control.

Indexed as

AedesAnimalsCitrus sinensisDengueDisease VectorsFemaleInsecticidesLarvaMosquito ControlPlant ExtractsPlant LeavesInsecticidesPlant ExtractsAedes aegyptiCitrusCitrus sinensisDengue vectorHexaneIrritancyIrritant activityLarvicidal activityLarvicideMosquito controlTake-offs

Identifiers

PMID23569887
PMCPMC3609257
OpenAlexW1965393027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.