ArticleAsian Pacific journal of tropical biomedicine2012
Anticancer property of sediment actinomycetes against MCF-7 and MDA-MB-231 cell lines.
Article in Asian Pacific journal of tropical biomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Exploring the anticancer potential of Streptomyces sp. M4 extract: effects on apoptosis in gastric cancer ags cells.Folia microbiologica · 2026Article
- Exploring marine-derived compounds as potential anti-cancer agents: Mechanisms and therapeutic implications.Cancer pathogenesis and therapy · 2026Review
- Green Synthesis of Chitosan-Coated Selenium Nanoparticles for Paclitaxel Delivery.Nanomaterials (Basel, Switzerland) · 2025Article
- Screening of Red Sea- and Mediterranean Sea-derived Actinomycetes for Antimicrobial and Antitumor activities: LC-ESI-HRMS-based Metabolomics Study.Microbial cell factories · 2025Article
- Actinomycetes: A Source of Anticancer Metabolites.Current medicinal chemistry · 2025Review
- Exploring the antimicrobial, antiviral, antioxidant, and antitumor potentials of marine Streptomyces tunisiensis W4MT573222 pigment isolated from Abu-Qir sediments, Egypt.Microbial cell factories · 2023Article
- Article
- Diversity and Biotechnological Potential of Marine Actinomycetes from India.Indian journal of microbiology · 2022Review
- Extraction, characterization, and anticancer potential of extracellular polymeric substances from marine actinobacteria ofJournal of advanced pharmaceutical technology & research · 2022Article
- Anti-cancer and antimicrobial potential of five soilRoyal Society open science · 2022Article
- Article
- A Comparison Study of Age and Colorectal Cancer-Related Gut Bacteria.Frontiers in cellular and infection microbiology · 2021Article
- Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes.Molecules (Basel, Switzerland) · 2020Review
- Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules.Antibiotics (Basel, Switzerland) · 2019Review
- Anti-MRSA activity of a bioactive compound produced by a marineIranian journal of basic medical sciences · 2019Article
- Dysbiosis of the Gut Microbiome in Lung Cancer.Frontiers in cellular and infection microbiology · 2019Article
- Optimization of the Cytotoxic Activity of ThreeBioMed research international · 2018Article
- Antioxidant and Anticancer Roles of a Novel Strain ofBioMed research international · 2018Article
- Profiling of red pigment produced by3 Biotech · 2018Article
- Statistical optimization and anticancer activity of a red pigment isolated from Streptomyces sp. PM4.Asian Pacific journal of tropical biomedicine · 2013Article
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Abstract
objectiveTo investigate the anticancer property of marine sediment actinomycetes against two different breast cancer cell lines.
methodsIn vitro anticancer activity was carried out against breast (MCF-7 and MDA-MB-231) cancer cell lines. Partial sequences of the 16s rRNA gene, phylogenetic tree construction, multiple sequence analysis and secondary structure analysis were also carried out with the actinomycetes isolates.
resultsOf the selected five actinomycete isolates, ACT01 and ACT02 showed the IC50 value with (10.13±0.92) and (22.34±5.82) µg/mL concentrations, respectively for MCF-7 cell line at 48 h, but ACT01 showed the minimum (18.54±2.49 µg/mL) level of IC50 value with MDA-MB-231 cell line. Further, the 16s rRNA partial sequences of ACT01, ACT02, ACT03, ACT04 and ACT05 isolates were also deposited in NCBI data bank with the accession numbers of GQ478246, GQ478247, GQ478248, GQ478249 and GQ478250, respectively. The phylogenetic tree analysis showed that, the isolates of ACT02 and ACT03 were represented in group I and III, respectively, but ACT01 and ACT02 were represented in group II. The multiple sequence alignment of the actinomycete isolates showed that, the maximum identical conserved regions were identified with the nucleotide regions of 125 to 221st base pairs, 65 to 119th base pairs and 55, 48 and 31st base pairs. Secondary structure prediction of the 16s rRNA showed that, the maximum free energy was consumed with ACT03 isolate (-45.4 kkal/mol) and the minimum free energy was consumed with ACT04 isolate (-57.6 kkal/mol).
conclusionsThe actinomycete isolates of ACT01 and ACT02 (GQ478246 and GQ478247) which are isolated from sediment sample can be further used as anticancer agents against breast cancer cell lines.
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