ArticleAsian Pacific journal of tropical biomedicine2012
Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats.
Article in Asian Pacific journal of tropical biomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 84 citations in OpenAlex.
- Trial
- Effects of an Herbal Combination on Glycemic Control and Lipid Profile in Diabetic Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Journal of evidence-based complementary & alternative medicine · 2017Trial
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- Evaluation of the efficicacy of myrcene in the treatment of Eimeria tenella and Toxoplasma gondii infection.The Journal of veterinary medical science · 2025Article
- Effects ofBioMed research international · 2023Article
- Impact of exercise on renal function, oxidative stress, and systemic inflammation among patients with type 2 diabetic nephropathy.African health sciences · 2022Article
- Phytochemical Contents and Pharmacological Potential ofAntioxidants (Basel, Switzerland) · 2022Review
- Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism.Molecules (Basel, Switzerland) · 2022Article
- A Study on How Methionine Restriction Decreases the Body's Hepatic and Lipid Deposition in Rice Field Eel (International journal of molecular sciences · 2021Article
- Investigating the effect of ethanolic extract ofJournal of diabetes and metabolic disorders · 2021Article
- Article
- Dietary Micronutrient Management to Treat Mitochondrial Dysfunction in Diet-Induced Obese Mice.International journal of molecular sciences · 2021Article
- Ameliorative effect of naringin against thiram-induced tibial dyschondroplasia in broiler chicken.Environmental science and pollution research international · 2020Article
- The effects of Commiphora mukul extract on spermatogenesis and testosterone levels in male diabetic rats.Clinical and experimental reproductive medicine · 2020Article
- Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer.Exploration of targeted anti-tumor therapy · 2020Review
- A panoramic view of medicinal plants traditionally applied for impotence and erectile dysfunction in Persian medicine.Journal of traditional and complementary medicine · 2020Review
- Probiotics isolated from yaks improves the growth performance, antioxidant activity, and cytokines related to immunity and inflammation in mice.Microbial cell factories · 2019Article
- Th1-Biased Immunomodulation and In Vivo Antitumor Effect of a Novel Piperine Analogue.International journal of molecular sciences · 2018Article
- Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the antioxidant efficacy of Commiphora mukul (C. mukul) gum resin ethanolic extract in streptozotocin (STZ) induced diabetic rats.
methodsTHE MALE WISTAR ALBINO RATS WERE RANDOMLY DIVIDED INTO FOUR GROUPS OF EIGHT ANIMALS EACH: Control group (C), CM-treated control group (C+CMEE), Diabetic control group (D), CM- treated diabetic group (D+CMEE). Diabetes was induced by intraperitoneal injection of STZ (55 mg/kg/ bwt). After being confirmed the diabetic rats were treated with C. mukul gum resin ethanolic extract (CMEE) for 60 days. The biochemical estimations like antioxidant, oxidative stress marker enzymes and hepatic marker enzymes of tissues were performed.
resultsThe diabetic rats showed increased level of enzymatic activities aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) in liver and kidney and oxidative markers like lipid peroxidation (LPO) and protein oxidation (PO) in pancreas and heart. Antioxidant enzyme activities were significantly decreased in the pancreas and heart compared to control group. Administration of CMEE (200 mg/kg bw) to diabetic rats for 60 days significantly reversed the above parameters towards normalcy.
conclusionsIn conclusion, our data indicate the preventive role of C. mukul against STZ-induced diabetic oxidative stress; hence this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes and aggravated antioxidant status.
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