ArticleAsian Pacific journal of tropical biomedicine2012
Preparation and characterization of curcumin-piperine dual drug loaded nanoparticles.
Article in Asian Pacific journal of tropical biomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Development and Implementation of Liposomal Encapsulated Micronutrient Fortified Body Oil Intervention for Infant Massage: An Innovative Concept to Prevent Micronutrient Deficiencies in Children.Frontiers in public health · 2020Trial
- Prospects of Plant Derived Bioactive Compounds as Nanoparticles for Biotechnological Applications.Recent patents on biotechnology · 2025Review
- Article
- Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment.Antioxidants (Basel, Switzerland) · 2024Review
- Curcumin Encapsulation in Geranium Oil Microemulsion Elevates Its Antibacterial, Antioxidant, Anti-Inflammatory, and Anticancer Activities.ACS omega · 2024Article
- Using Spent Brewer's Yeast to Encapsulate and Enhance the Bioavailability of Sonochemically Nanostructured Curcumin.International journal of food science · 2024Article
- Nanocurcumin in myocardial infarction therapy: emerging trends and future directions.Frontiers in bioengineering and biotechnology · 2024Review
- Exploring Nanocarriers as Treatment Modalities for Skin Cancer.Molecules (Basel, Switzerland) · 2023Review
- Preparation and Characterization of Nanosuspensions of Triiodoaniline Derivative New Contrast Agent, and Investigation into Its Cytotoxicity and Contrast Properties.Iranian journal of pharmaceutical research : IJPR · 2022Article
- Dual-Enhanced Pluronic Nanoformulated Methotrexate-Based Treatment Approach for Breast Cancer: Development and Evaluation of In Vitro and In Vivo Efficiency.Pharmaceutics · 2022Article
- Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia.Pharmaceutics · 2020Article
- Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin.Nutrients · 2020Review
- Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases.International journal of molecular sciences · 2018Review
- Development of RP-HPLC method for simultaneous determination of docetaxel and curcumin in rat plasma: Validation and stability.Asian journal of pharmaceutical sciences · 2017Article
- Effects of piperine on the intestinal permeability and pharmacokinetics of linarin in rats.Molecules (Basel, Switzerland) · 2014Article
- Future directions in the prevention of prostate cancer.Nature reviews. Clinical oncology · 2014Review
- Drug-Drug/Drug-Excipient Compatibility Studies on Curcumin using Non-Thermal Methods.Advanced pharmaceutical bulletin · 2014Article
- Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice.Cancer research and treatment · 2014Review
- Modifications to the conventional nanoprecipitation technique: an approach to fabricate narrow sized polymeric nanoparticles.Advanced pharmaceutical bulletin · 2014Article
- Protective effects of Vernonia amygdalina against sodium arsenite-induced genotoxicity in rat.Pharmacognosy research · 2013Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
objectiveTo prepare curcumin-piperine (Cu-Pi) nanoparticles by various methods and to study the effect of various manufacturing parameters on Cu-Pi nanoparticles and to identify a suitable method for the preparation of Cu-Pi nanoparticles to overcome oral bioavailability and cancer cell targeting limitations in the treatment of cancer.
methodsCu-Pi nanoparticles were prepared by thin film hydration method, solid dispersion method, emulsion polymerization method and Fessi method. Optimization was carried out to study the effect of various manufacturing parameter on the Cu-Pi nanoparticles.
resultsOut of four methods, Fessi method produced a minimum average particle size of 85.43 nm with a polydispersity index of 0.183 and zeta potential of 29.7 mV. Change of organic solvent (acetone or ethanol) did not have any significant effect on Cu-Pi nanoparticles. However, increase in sonication time, stirring speed, viscosity, use of 1:10:10 ratio of drug/polymer/surfactant, and use of anionic surfactant or combination of anionic surfactant with cationic polymer or combination of non-ionic surfactant with cationic polymer had a significant effect on Cu-Pi nanoparticles.
conclusionsCu-Pi nanoparticles coated with PEG containing copolymer produced by Fessi method had a minimum average particle size, excellent polydispersity index and optimal zeta potential which fall within the acceptable limits of the study. This dual nanoparticulate drug delivery system appears to be promising to overcome oral bioavailability and cancer cell targeting limitations in the treatment of cancer.
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