ArticleThe American journal of case reports2012
Unilateral conjunctival AL kappa amyloidosis with trace evidence of systemic amyloidosis.
Article in The American journal of case reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Long-Term Follow-Up of 4 Patients with Conjunctival Amyloidosis.Ocular oncology and pathology · 2018Article
- A Case of Conjunctival Amyloidosis with Repeated Subconjunctival Hemorrhage.Case reports in ophthalmological medicine · 2017Article
- Ocular adnexal and orbital amyloidosis: a case series and literature review.International ophthalmology · 2016Review
- Conjunctival amyloidosis -- clinical and histopathologic features.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Systemic amyloidosis with bilateral conjunctival involvement: a case report.BMC ophthalmology · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmyloidosis is a systemic disorder that results from the tissue deposition of various proteins with distinctive morphological characteristics. Conjunctival amyloidosis is a rare variant which is generally localized and not associated with systemic involvement. CASE REPORT: We present here a case of 47-year-old female patient with right eyelid swelling that progressed over a 12 year period and eventually underwent surgery with pathology showing AL conjunctival amyloidosis. Unlike in most other reported cases of localized amyloidosis, she was noted to have amyloid deposition in the bone marrow and gastrointestinal tract upon extensive evaluation without any evidence of underlying plasma cell dyscrasia. She has been on observation without evidence of systemic progression or recurrence of conjunctival amyloid.
conclusionsAlthough it initially appeared that our case represented an isolated form of AL (kappa)-type conjunctival amyloidosis, systemic evaluation revealed trace amount of amyloid in the bone marrow and GI tract. It is feasible that upon very close scrutiny patients with seemingly localized AL amyloidosis may have trace amounts of amyloid involving other organs and based on experience from this single patient we believe that it is safe to observe such patients closely rather than pursue systemic therapy.
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