ArticleGenetics and molecular biology2013
Crude alkaloid extract of Rhazya stricta inhibits cell growth and sensitizes human lung cancer cells to cisplatin through induction of apoptosis.
Article in Genetics and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Comparative phytochemical, antioxidant, and hemostatic studies of leaf and stem extracts ofFrontiers in molecular biosciences · 2026Article
- Antiviral potential of Melissa officinalis extracts against influenza and emerging coronaviruses.Scientific reports · 2025Article
- Ethyl acetate extract ofFrontiers in pharmacology · 2025Article
- Antiviral activity ofFrontiers in pharmacology · 2025Article
- A Novel Integrated Approach: Plant-Mediated Synthesis, in vitro and in silico Evaluation of Silver Nanoparticles for Breast Cancer and Bacterial Therapies.International journal of nanomedicine · 2025Article
- Impact of SWCNT-conjugated senna leaf extract on breast cancer cells: A potential apoptotic therapeutic strategy.Open life sciences · 2024Article
- Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation inPlants (Basel, Switzerland) · 2019Article
- Apoptotic Induction and Anti-Migratory Effects ofMolecules (Basel, Switzerland) · 2019Article
- ITS2: An Ideal DNA Barcode for the Arid Medicinal Plant Rhazya Stricta.Pharmaceutical medicine · 2019Article
- Antioxidant and anticancer activities of Trigonella foenum-graecum, Cassia acutifolia and Rhazya stricta.BMC complementary and alternative medicine · 2018Article
- Natural products: a hope for glioblastoma patients.Oncotarget · 2018Review
- In vitro induction of human embryonal carcinoma differentiation by a crude extract of Rhazya stricta.BMC complementary and alternative medicine · 2017Article
- Cheminformatics studies to analyze the therapeutic potential of phytochemicals fromChemistry Central journal · 2017Article
- Assessment of biological activity and UPLC-MS based chromatographic profiling of ethanolic extract of Ochradenus arabicus.Saudi journal of biological sciences · 2016Article
- Establishment of transgenic Rhazya stricta hairy roots to modulate terpenoid indole alkaloid production.Plant cell reports · 2015Article
- An Investigation of the Growth Inhibitory Capacity of Several Medicinal Plants From Iran on Tumor Cell Lines.Iranian journal of cancer prevention · 2015Article
- Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells.Cell proliferation · 2015Article
- Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination.World journal of gastroenterology · 2014Article
- Effects of crude extracts from medicinal herbs Rhazya stricta and Zingiber officinale on growth and proliferation of human brain cancer cell line in vitro.BioMed research international · 2014Article
- Rhazyaminine from Rhazya stricta Inhibits Metastasis and Induces Apoptosis by Downregulating Bcl-2 Gene in MCF7 Cell Line.Integrative cancer therapiesArticle
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
There is an urgent need to improve the clinical management of non-small cell lung cancer (NSCLC), one of the most frequent causes of cancer-related deaths in men and women worldwide. Rhazya stricta, an important medicinal plant used in traditional Oriental medicine, possesses anti-oxidant, anti-carcinogenic and free radical scavenging properties. This study was done to explore the potential anticancer activity of a crude alkaloid extract of R. stricta (CAERS) against the NSCLC line A549. CAERS markedly suppressed the growth of A549 cells and considerably enhanced the anti-proliferative potential of cisplatin. CAERS-mediated inhibition of A549 cell growth correlated with the induction of apoptosis that was accompanied by numerous morphological changes, DNA fragmentation, an increase in the Bax/Bcl-2 ratio, the release of mitochondrial cytochrome c, activation of caspases 3 and 9 and cleavage of poly(ADP-ribose)-polymerase. CAERS reduced the constitutive expression of anti-apoptotic proteins (Bcl-2, Bcl-XL, Mcl-1 and Survivin) and cell cycle regulating proteins (cyclin D1 and c-Myc), but enhanced expression of the proapoptotic proteins Noxa and BAD. These observations indicate that CAERS induced apoptosis and sensitized NSCLC to cisplatin via a mitochondria-mediated apoptotic pathway. These data provide a rationale for using a combination of CAERS and CDDP to treat NSCLC and other CDDP-resistant tumors.
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