ArticleThe Journal of experimental medicine2013
Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages.
Article in The Journal of experimental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Potential Role for the Ubiquitin Ligase SIAH2 in Modulating Bone Morphology and Adiposity.Calcified tissue international · 2026Article
- Single-cell analysis of ecto-mesenchymal cells derived from the neural crest reveals the regulatory role of P75NTR in odontogenic and osteogenic differentiation.BMC oral health · 2025Article
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- Expression of the preadipocyte marker ZFP423 is dysregulated between well-differentiated and dedifferentiated liposarcoma.BMC cancer · 2022Article
- EBF1 is expressed in pericytes and contributes to pericyte cell commitment.Histochemistry and cell biology · 2021Article
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- SIAH2 is Expressed in Adipocyte Precursor Cells and Interacts with EBF1 and ZFP521 to Promote Adipogenesis.Obesity (Silver Spring, Md.) · 2021Article
- The ClassicGenetics · 2020Article
- Patient genetics is linked to chronic wound microbiome composition and healing.PLoS pathogens · 2020Article
- Osteoclastogenesis inhibition by mutated IGSF23 results in human osteopetrosis.Cell proliferation · 2019Article
- Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation.Molecular and cellular biology · 2019Article
- ZNF521 Represses Osteoblastic Differentiation in Human Adipose-Derived Stem Cells.International journal of molecular sciences · 2018Article
- ZNF521 Has an Inhibitory Effect on the Adipogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells.Stem cell reviews and reports · 2018Article
- Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment.Molecular and cellular biology · 2018Article
- ZNF423: A New Player in Estrogen Receptor-Positive Breast Cancer.Frontiers in endocrinology · 2018Review
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- Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis.Genes & development · 2016Article
- Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13.Genesis (New York, N.Y. : 2000) · 2016Article
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Authors and funding
17 authors at 10 institutions in 4 countries.
Funding
Abstract
Bone homeostasis is maintained by the coupled actions of hematopoietic bone-resorbing osteoclasts (OCs) and mesenchymal bone-forming osteoblasts (OBs). Here we identify early B cell factor 1 (Ebf1) and the transcriptional coregulator Zfp521 as components of the machinery that regulates bone homeostasis through coordinated effects in both lineages. Deletion of Zfp521 in OBs led to impaired bone formation and increased OB-dependent osteoclastogenesis (OC-genesis), and deletion in hematopoietic cells revealed a strong cell-autonomous role for Zfp521 in OC progenitors. In adult mice, the effects of Zfp521 were largely caused by repression of Ebf1, and the bone phenotype of Zfp521(+/-) mice was rescued in Zfp521(+/-):Ebf1(+/-) mice. Zfp521 interacted with Ebf1 and repressed its transcriptional activity. Accordingly, deletion of Zfp521 led to increased Ebf1 activity in OBs and OCs. In vivo, Ebf1 overexpression in OBs resulted in suppressed bone formation, similar to the phenotype seen after OB-targeted deletion of Zfp521. Conversely, Ebf1 deletion led to cell-autonomous defects in both OB-dependent and cell-intrinsic OC-genesis, a phenotype opposite to that of the Zfp521 knockout. Thus, we have identified the interplay between Zfp521 and Ebf1 as a novel rheostat for bone homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.