Evidence map›Paper›PMID 23569293›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013

Social environment influences the relationship between genotype and gene expression in wild baboons.

Daniel E Runcie, Ralph T Wiedmann, Elizabeth A Archie, Jeanne Altmann, Gregory A Wray, Susan C Alberts, Jenny Tung

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Evolutionary Approaches in Aging Research.Cold Spring Harbor perspectives in medicine · 2022
    Review
  5. Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Adaptations for social cognition in the primate brain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Review
  11. Article
  12. Article
  13. Social environmental effects on gene regulation.Cellular and molecular life sciences : CMLS · 2013
    Review
  14. Developmental constraints on behavioural flexibility.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013
    Review
  15. Taking note of Tinbergen, or: the promise of a biology of behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013
    Review
  16. Constraints and flexibility in mammalian social behaviour: introduction and synthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Daniel E RuncieDepartment of Biology, Duke University, Durham, NC 27708, USA.
Ralph T Wiedmann
Elizabeth A Archie
Jeanne Altmann
Gregory A Wray
Susan C Alberts
Jenny Tung
Institute of Primate Research · KEDuke University · USNational Museums of Kenya · KERoman L. Hruska U.S. Meat Animal Research Center · US

Funding

THE RANGE OF MALE-FEMALE MORTALITY DIFFERENCESP01AG031719 · NIA · DUKE UNIVERSITY · PI ZENG, YI · 2009 to 2020
$10.2M
Mechanisms and Consequences of Social Connectedness in a Wild Primate PopulationR01AG034513 · NIA · DUKE UNIVERSITY · PI ALBERTS, SUSAN C. · 2009 to 2013
$1.8M
NIA NIH HHS P01 AG031719NIA NIH HHS P01-AG031719NIA NIH HHS R01 AG034513NIA NIH HHS R01-AG034513-01
6 · The paper itself

Abstract

Variation in the social environment can have profound effects on survival and reproduction in wild social mammals. However, we know little about the degree to which these effects are influenced by genetic differences among individuals, and conversely, the degree to which social environmental variation mediates genetic reaction norms. To better understand these relationships, we investigated the potential for dominance rank, social connectedness and group size to modify the effects of genetic variation on gene expression in the wild baboons of the Amboseli basin. We found evidence for a number of gene-environment interactions (GEIs) associated with variation in the social environment, encompassing social environments experienced in adulthood as well as persistent effects of early life social environment. Social connectedness, maternal dominance rank and group size all interacted with genotype to influence gene expression in at least one sex, and either in early life or in adulthood. These results suggest that social and behavioural variation, akin to other factors such as age and sex, can impact the genotype-phenotype relationship. We conclude that GEIs mediated by the social environment are important in the evolution and maintenance of individual differences in wild social mammals, including individual differences in responses to social stressors.

Indexed as

Behavior, AnimalGene ExpressionSocial EnvironmentAllelesAnimalsCompetitive BehaviorFemaleGene-Environment InteractionGenotypeMalePapioPolymorphism, Single NucleotideRegulatory Sequences, Nucleic AcidSex FactorsSocial Dominance

Identifiers

PMID23569293
PMCPMC3638448
OpenAlexW2138276752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.