ArticleInternational journal of epidemiology2013
A U-shaped relationship between haematocrit and mortality in a large prospective cohort study.
Article in International journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Endogenous Sex Steroid Hormones, Sex Hormone-Binding Globulin, and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.The Journal of clinical endocrinology and metabolism · 2025Pooled it
- Article
- Hematocrit and 28-day mortality in mechanically ventilated septic patients: a prospective observational study.Frontiers in medicine · 2026Article
- A U shaped association between the HCT-ALB and hospital mortality in patients with sepsis.Scientific reports · 2025Observational
- Nonlinear association between hematocrit levels and short-term all-cause mortality in ICU patients with acute pancreatitis: insights from a retrospective cohort study.BMC gastroenterology · 2025Article
- Child-parent associations of hematocrit in trios of Japanese adulthood confirmed by the random family method: The TMM BirThree Cohort Study.Scientific reports · 2024Article
- Hematocrit drift and outcomes in surgical patients with aneurysmal subarachnoid hemorrhage.Acta neurochirurgica · 2024Article
- Risk Factors of In-Hospital Venous Thromboembolism and Prognosis After Emergent Ventral Hernia Repair.Emergency medicine international · 2024Article
- Preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumors.Frontiers in oncology · 2023Article
- Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy.The Journal of urology · 2022Article
- Article
- Hematocrit, age, and survival in a wild vertebrate population.Ecology and evolution · 2021Article
- Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies.PloS one · 2020Article
- Hematological parameters and all-cause mortality: a prospective study of older people.Aging clinical and experimental research · 2018Article
- Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study.Scientific reports · 2018Article
- The effect of age on the shape of the BMI-mortality relation and BMI associated with minimum all-cause mortality in a large Austrian cohort.International journal of obesity (2005) · 2015Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundOnly a limited number of studies have investigated the correlation between haematocrit (HCT) and mortality in the general population, and few of those studies have had data on a wide range of low and high levels of HCT. We investigated the association between baseline HCT and mortality in a prospective cohort study of 49,983 adult subjects in Iran with a broad spectrum of HCT values.
methodsData on socio-demographic and life-style factors, past medical history, and levels of HCT were collected at enrollment. During a mean follow-up of 5 years (follow-up success rate ~99%), 2262 deaths were reported. Cox proportional hazards regression models were used to estimate hazard ratios and corresponding 95% confidence intervals.
resultsThere was a U-shaped relationship between categories of HCT and mortality in both sexes: both low and high levels of HCT were associated with increased overall mortality and mortality from cardiovascular disease. The U-shaped relationship persisted after several sensitivity analyses were done, including analyses restricted to non-smokers and non-users of opium; analyses excluding deaths from accidents and other external causes as well as deaths of persons with self-reported ischemic heart disease at the baseline interview for the study; and analyses excluding the first 2 years of follow-up. Self-reported past medical history and lack of data about lipids and other cellular blood components were the major limitations of the study.
conclusionsLow and high levels of HCT are associated with increased mortality in the general population. The findings in the present study can be of particular importance for low- and middle-income countries in which a substantial proportion of the population lives with suboptimal levels of HCT.
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