ArticleInternational journal of epidemiology2013
Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies.
Article in International journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Pooled it
- The role of nutrition in harnessing the immune system: a potential approach to prevent cancer.Medical oncology (Northwood, London, England) · 2022Pooled it
- Systematic review and meta-analysis of studies assessing the relationship between statin use and risk of ovarian cancer.Cancer causes & control : CCC · 2020Pooled it
- The differential distribution of bacteria between cancerous and noncancerous ovarian tissues in situ.Journal of ovarian research · 2020Trial
- Differences in risk for type 1 and type 2 ovarian cancer in a large cancer screening trial.Journal of gynecologic oncology · 2016Trial
- Ovarian cancer in Asia: incidence, mortality in 2022, and future projections to 2050.BMC public health · 2026Article
- Hidden Burden of Fallopian Tube Endometriosis: Prevalence and Associations with Pelvic Pathology.Journal of clinical medicine · 2026Article
- Willingness to use female permanent contraception among married women and male partners´ support in Benue, Nigeria.The Pan African medical journal · 2025Article
- Molecular Pathology of Ovarian Endometrioid Carcinoma: A Review.Oncology research · 2025Review
- Racial and ethnic differences in epithelial ovarian cancer risk: an analysis from the Ovarian Cancer Association Consortium.American journal of epidemiology · 2024Article
- Global epidemiology of epithelial ovarian cancer.Nature reviews. Clinical oncology · 2024Review
- Review
- Ovarian Cancer: From Precursor Lesion Identification to Population-Based Prevention Programs.Current oncology (Toronto, Ont.) · 2023Review
- Vaginal bacteria elicit acute inflammatory response in fallopian tube organoids: a model for pelvic inflammatory disease.Research square · 2023Article
- Outcomes From Opportunistic Salpingectomy for Ovarian Cancer Prevention.JAMA network open · 2022Article
- Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association.Gynecologic oncology · 2022Article
- Ovarian Cancer Risk Factor Associations by Primary Anatomic Site: The Ovarian Cancer Cohort Consortium.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Article
- Associations of CXCL1 gene 5'UTR variations with ovarian cancer.Journal of ovarian research · 2020Article
- Prophylactic salpingectomy for prevention of ovarian cancer at the time of elective laparoscopic cholecystectomy.The British journal of surgery · 2020Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
39 authors.
Funding
Abstract
backgroundTubal ligation is a protective factor for ovarian cancer, but it is unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study to examine the association between tubal ligation and ovarian cancer subtypes.
methodsWe pooled primary data from 13 population-based case-control studies, including 10,157 patients with ovarian cancer (7942 invasive; 2215 borderline) and 13,904 control women. Invasive cases were analysed by histological type, grade and stage, and borderline cases were analysed by histological type. Pooled odds ratios were estimated using conditional logistic regression to match on site, race/ethnicity and age categories, and to adjust for age, oral contraceptive use duration and number of full-term births.
resultsTubal ligation was associated with significantly reduced risks of invasive serous (OR, 0.81; 95% CI, 0.74-0.89; P < 0.001), endometrioid (OR, 0.48; 95% CI, 0.40-0.59; P < 0.001), clear cell (OR, 0.52; 95% CI, 0.40-0.67; P < 0.001) and mucinous (OR, 0.68; 95% CI, 0.52-0.89; P = 0.005) cancers. The magnitude of risk reduction was significantly greater for invasive endometrioid (P < 0.0001) and clear cell (P = 0.0018) than for serous cancer. No significant associations were found with borderline serous or mucinous tumours.
conclusionsWe found that the protective effects of tubal ligation on ovarian cancer risk were subtype-specific. These findings provide insights into distinct aetiologies of ovarian cancer subtypes and mechanisms underlying the protective effects of tubal ligation.
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