ArticleInternational journal of epidemiology2013
ALPK1 genetic regulation and risk in relation to gout.
Article in International journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout.Journal of human genetics · 2018Trial
- Machine learning identifies MiRNA biomarkers and immune mechanisms in active tuberculosis.Scientific reports · 2025Article
- Investigating the role of the ALPK1 signaling pathway in the pathogenesis of diabetic retinopathy.Scientific reports · 2025Article
- The importance of ALPK1 kinase functionality as a potential biomarker for inflammatory diseases.Molecular biology reports · 2025Review
- Advancing Gouty Arthritis Research: The Clinical Value of Complete Blood Cell Count Ratios and Immune-Inflammatory Interactions.Journal of inflammation research · 2025Review
- Systemic inflammation response index association with gout in hyperuricemic adults: NHANES 2007-2018.Frontiers in medicine · 2024Article
- A Bittersweet Kiss of Gram-Negative Bacteria: The Role of ADP-Heptose in the Pathogenesis of Infection.Microorganisms · 2023Review
- In vitro kinase assay reveals ADP-heptose-dependent ALPK1 autophosphorylation and altered kinase activity of disease-associated ALPK1 mutants.Scientific reports · 2023Article
- Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases.Cancers · 2022Review
- Long noncoding RNA HAR1A regulates oral cancer progression through the alpha-kinase 1, bromodomain 7, and myosin IIA axis.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Implicating causal brain imaging endophenotypes in Alzheimer's disease using multivariable IWAS and GWAS summary data.NeuroImage · 2020Article
- ALPK1 regulates streptozotocin-induced nephropathy through CCL2 and CCL5 expressions.Journal of cellular and molecular medicine · 2019Article
- ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.Nature communications · 2019Article
- ALPK1: innate attraction to the sweetness of bacteria.Cell research · 2018Article
- Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.Nature communications · 2018Article
- Risk of incident benign prostatic hyperplasia in patients with gout: a retrospective cohort study.Prostate cancer and prostatic diseases · 2018Article
- Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis.Medicine · 2018Article
- Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.The open rheumatology journal · 2018Review
- ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria.PLoS pathogens · 2017Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundThe present study investigated whether single nucleotide polymorphisms (SNPs) in the alpha-protein kinase 1 (ALPK1) gene are associated with gout in aboriginal and Han Chinese Taiwanese.
methodsA total of 1351 aborigines from the community (511 cases and 840 controls) and 511 Han people from hospital (104 cases and 407 controls) were recruited. SNPs in potentially functional regions of the 38 genes within 4q25 were identified and genotypes determined by direct sequencing. Quantitation of blood ALPK1 mRNA expression levels and luciferase assay of gout-associated rs231253 pGL3-SNP constructs cotransfected with hsa-miR-519e were examined.
resultsWe found that ALPK1 gene was the most determinant of gout. Three SNPs of rs11726117 M861T [C], rs231247 [G] and rs231253 [G] were most associated with gout risk [odd ratios (OR) ≥1.44, P ≤ 3.78 × 10(-6)) in aborigines. A replication set using Han people had risk at rs11726117 and rs231247 (OR ≥1.72, P ≤ 4.08 × 10(-3)). From pooled analysis (Breslow-Day test, P > 0.33) assuming an additive model, each increasing copy of the risk allele of rs11726117 [C], rs231247 [G] and rs231253 [G] showed significantly elevated OR for gout ≥1.42 (P ≥ 1.53 × 10(-6)). Consistently, the composite homozygous of linked 3 SNPs (versus wild-type, OR = 1.83, P = 8.21 × 10(-4)) had strong associations with ALPK1 mRNA expression. Luciferase showed reduced hybridization between hsa-miR-519e and construct carrying gout-associated rs231253 [G] than the wild-type [C] (P = 6.19 × 10(-4)).
conclusionsOur study found that a newly identified ALPK1 gene can effectively interfere with microRNA target recognition and modulates the mRNA expression; and the varying distribution of the implicated SNPs among cases and controls in the two studied populations suggests a significant role in gout susceptibility.
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