ArticleJournal of wildlife diseases2013
Fatal herpesvirus hemorrhagic disease in wild and orphan asian elephants in southern India.
Article in Journal of wildlife diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 72 citations in OpenAlex.
- Prevalence of Elephant Endotheliotropic Herpesvirus (EEHV) in Wild and Captive Bornean Elephants (Animals : an open access journal from MDPI · 2026Article
- Neutrophil extracellular traps offer a new therapeutic target for elephant endotheliotropic herpes virus-hemorrhagic disease (EEHV-HD).Communications biology · 2026Article
- Article
- Viral metagenomics of Okavango Delta water pans reveal novel insights into wildlife disease potential.iMetaOmics · 2025Article
- Tissue and cellular tropism of elephant endotheliotropic herpesvirus (EEHV)1A in hemorrhagic disease.PloS one · 2025Article
- Epidemiological, serological, and viral genomic analysis of an outbreak of elephant hemorrhagic disease in Switzerland.PloS one · 2025Article
- Young elephants in a large herd maintain high levels of elephant endotheliotropic herpesvirus-specific antibodies and do not succumb to fatal haemorrhagic disease.Transboundary and emerging diseases · 2022Article
- Article
- Elephant Endotheliotropic Herpesvirus 4 andAnimals : an open access journal from MDPI · 2022Article
- Article
- Clinical characteristics of elephant endotheliotropic herpesvirus (EEHV) cases in Asian elephants (The veterinary quarterly · 2021Article
- The first reported cases of elephant endotheliotropic herpesvirus infectious haemorrhagic disease in Malaysia: case report.Virology journal · 2021Article
- Elephant Endotheliotropic Herpesvirus Impact in the European Asian Elephant (Animals : an open access journal from MDPI · 2021Article
- Retrospective review of 27 European cases of fatal elephant endotheliotropic herpesvirus-haemorrhagic disease reveals evidence of disseminated intravascular coagulation.Scientific reports · 2021Article
- The occurrence of elephant endotheliotropic herpesvirus infection in wild and captive Asian elephants in Thailand: Investigation based on viral DNA and host antibody.Veterinary world · 2021Article
- Successful treatment of elephant endotheliotropic herpesvirus infection in an Asian elephant (Elephas maximus) calf by oral acyclovir medication: Case report.The Journal of veterinary medical science · 2021Article
- Patterns of serum immune biomarkers during elephant endotheliotropic herpesvirus viremia in Asian and African elephants.PloS one · 2021Article
- Article
- Serum Health Biomarkers in African and Asian Elephants: Value Ranges and Clinical Values Indicative of the Immune Response.Animals : an open access journal from MDPI · 2020Article
- Elephant Endotheliotropic Herpesvirus Hemorrhagic Disease in Asian Elephant Calves in Logging Camps, Myanmar.Emerging infectious diseases · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Up to 65% of deaths of young Asian elephants (Elephas maximus) between 3 mo and 15 yr of age in Europe and North America over the past 20 yr have been attributed to hemorrhagic disease associated with a novel DNA virus called elephant endotheliotropic herpesvirus (EEHV). To evaluate the potential role of EEHV in suspected cases of a similar lethal acute hemorrhagic disease occurring in southern India, we studied pathologic tissue samples collected from field necropsies. Nine cases among both orphaned camp and wild Asian elephants were identified by diagnostic PCR. These were subjected to detailed gene subtype DNA sequencing at multiple PCR loci, which revealed seven distinct strains of EEHV1A and one of EEHV1B. Two orphan calves that died within 3 days of one another at the same training camp had identical EEHV1A DNA sequences, indicating a common epidemiologic source. However, the high level of EEHV1 subtype genetic diversity found among the other Indian strains matches that among over 30 EEHV1 strains that have been evaluated from Europe and North America. These results argue against the previous suggestions that this is just a disease of captive elephants and that the EEHV1 virus has crossed recently from African elephant (Loxodonta africana) hosts to Asian elephants. Instead, both the virus and the disease are evidently widespread in Asia and, despite the disease severity, Asian elephants appear to be the ancient endogenous hosts of both EEHV1A and EEHV1B.
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Registered trials
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