ArticleMagnetic resonance in medicine2014
Clinically viable magnetic poly(lactide-co-glycolide) particles for MRI-based cell tracking.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Challenges and Practical Solutions to MRI and Histology Matching and Measurements Using Available ImageJ Software Tools.Biomedicines · 2022Article
- PLGA-Based Composites for Various Biomedical Applications.International journal of molecular sciences · 2022Review
- Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment.Scientific reports · 2021Article
- Design Considerations to Facilitate Clinical Radiological Evaluation of Implantable Biomedical Structures.ACS biomaterials science & engineering · 2021Article
- Tissue-Specific Ferritin- and GFP-Based Genetic Vectors Visualize Neurons by MRI in the Intact and Post-Ischemic Rat Brain.International journal of molecular sciences · 2020Article
- Complex Relationship Between Iron Oxide Nanoparticle Degradation and Signal Intensity in Magnetic Particle Imaging.ACS applied nano materials · 2020Article
- Enabling biodegradable functional biomaterials for the management of neurological disorders.Advanced drug delivery reviews · 2019Review
- Intracellular processing of silica-coated superparamagnetic iron nanoparticles in human mesenchymal stem cells.RSC advances · 2019Article
- Magnetic Resonance Imaging for tracking cellular patterns obtained by Laser-Assisted Bioprinting.Scientific reports · 2018Article
- Nanoparticle-Mediated Cell Capture Enables Rapid Endothelialization of a Novel Bare Metal Stent.Tissue engineering. Part A · 2018Article
- Liver cell therapy: is this the end of the beginning?Cellular and molecular life sciences : CMLS · 2018Review
- Tracking Neural Progenitor Cell Migration in the Rodent Brain Using Magnetic Resonance Imaging.Frontiers in neuroscience · 2018Review
- In Vivo Molecular MRI of ICAM-1 Expression on Endothelium and Leukocytes from Subacute to Chronic Stages After Experimental Stroke.Translational stroke research · 2017Article
- Advances in Monitoring Cell-Based Therapies with Magnetic Resonance Imaging: Future Perspectives.International journal of molecular sciences · 2017Review
- Siloxane Nanoprobes for Labeling and Dual Modality Functional Imaging of Neural Stem Cells.Annals of biomedical engineering · 2016Article
- Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles.Journal of visualized experiments : JoVE · 2015Article
- Imaging transplanted stem cells in real time using an MRI dual-contrast method.Scientific reports · 2015Article
- Biodegradable, polymer encapsulated, metal oxide particles for MRI-based cell tracking.Magnetic resonance in medicine · 2015Review
- Magnetic cell labeling of primary and stem cell-derived pig hepatocytes for MRI-based cell tracking of hepatocyte transplantation.PloS one · 2015Article
- Dual-modality, fluorescent, PLGA encapsulated bismuth nanoparticles for molecular and cellular fluorescence imaging and computed tomography.Nanoscale · 2014Article
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6 authors.
Funding
Abstract
purposeTo design, fabricate, characterize, and in vivo assay clinically viable magnetic particles for MRI-based cell tracking.
methodsPoly(lactide-co-glycolide) (PLGA) encapsulated magnetic nano and microparticles were fabricated. Multiple biologically relevant experiments were performed to assess cell viability, cellular performance, and stem cell differentiation. In vivo MRI experiments were performed to separately test cell transplantation and cell migration paradigms, as well as in vivo biodegradation.
resultsHighly magnetic nano (∼100 nm) and microparticles (∼1-2 µm) were fabricated. Magnetic cell labeling in culture occurred rapidly achieving 3-50 pg Fe/cell at 3 h for different particles types, and >100 pg Fe/cell after 10 h, without the requirement of a transfection agent, and with no effect on cell viability. The capability of magnetically labeled mesenchymal or neural stem cells to differentiate down multiple lineages, or for magnetically labeled immune cells to release cytokines following stimulation, was uncompromised. An in vivo biodegradation study revealed that NPs degraded ∼80% over the course of 12 weeks. MRI detected as few as 10 magnetically labeled cells, transplanted into the brains of rats. Also, these particles enabled the in vivo monitoring of endogenous neural progenitor cell migration in rat brains over 2 weeks.
conclusionThe robust MRI properties and benign safety profile of these particles make them promising candidates for clinical translation for MRI-based cell tracking.
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