Evidence map›Paper›PMID 23568508›Full record

ArticleChemMedChem2013

Rhenium complexes with visible-light-induced anticancer activity.

Anja Kastl, Sandra Dieckmann, Kathrin Wähler, Timo Völker, Lena Kastl, Anna Lena Merkel, Adina Vultur, Batool Shannan, Klaus Harms, Matthias Ocker and 3 more

Open access · greenAbstract read
In one paragraph

Article in ChemMedChem, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 85 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Review
  7. Review
  8. Article
  9. Cytotoxicity, cellular localization and photophysical properties of Re(I) tricarbonyl complexes bound to cysteine and its derivatives.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Article
  10. Organometallic rhenium tricarbonyl-enrofloxacin and -levofloxacin complexes: synthesis, albumin-binding, DNA-interaction and cell viability studies.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019
    Article
  11. Article
  12. Crystal structure of theActa crystallographica. Section E, Crystallographic communications · 2017
    Article
  13. Article
  14. Article
  15. Developing strategies to predict photodynamic therapy outcome: the role of melanoma microenvironment.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Review
  16. Rhenium Complexes with Red-Light-Induced Anticancer Activity.European journal of inorganic chemistry · 2014
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Anja KastlFachbereich Chemie, Philipps-Universität Marburg, Marburg, Germany.
Sandra Dieckmann
Kathrin Wähler
Timo Völker
Lena Kastl
Anna Lena Merkel
Adina Vultur
Batool Shannan
Klaus Harms
Matthias Ocker
Wolfgang J Parak
Meenhard Herlyn
Eric Meggers
Philipps University of Marburg · DEThe Wistar Institute · USXiamen University · CN

Funding

Targeting the MAP and PI3 Kinase Pathways in MelanomaP01CA114046 · NCI · WISTAR INSTITUTE · PI MURPHY, MAUREEN E. · 2008 to 2023
$37.1M
NCI NIH HHS CA114046NCI NIH HHS P01 CA114046
6 · The paper itself

Abstract

Shedding light on the matter: Rhenium(I) indolato complexes with highly potent visible-light-triggered antiproliferative activity (complex 1: EC50 light=0.1 μM vs EC50 dark=100 μM) in 2D- and 3D-organized cancer cells are reported and can be traced back to an efficient generation of singlet oxygen, causing rapid morphological changes and an induction of apoptosis.

Indexed as

LightAntineoplastic AgentsCell ProliferationCrystallography, X-RayDose-Response Relationship, DrugDrug Screening Assays, AntitumorHeLa CellsHumansModels, MolecularMolecular StructureOrganometallic CompoundsRheniumStructure-Activity RelationshipAntineoplastic AgentsOrganometallic CompoundsRhenium

Identifiers

PMID23568508
PMCPMC3665699
OpenAlexW2130276070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.