ArticleWorld journal of urology2013
Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma: an analysis of the multicenter CORONA database.
Article in World journal of urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- A Web-Based Prediction Model for Cancer-Specific Survival of Elderly Patients With Clear Cell Renal Cell Carcinoma: A Population-Based Study.Frontiers in public health · 2021Trial
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- The correlation between clinical and pathological features of renal cancer patients with survival after surgical intervention.Caspian journal of internal medicine · 2026Article
- Deciphering RCC immunotherapy outcomes: insights from a Japanese multi-institutional study on the CANLPH score's impact.World journal of urology · 2025Article
- Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8Biology of sex differences · 2023Article
- Molecular differences in renal cell carcinoma between males and females.World journal of urology · 2023Review
- Review
- Predictive Ability for Disease-Free Survival of the GRade, Age, Nodes, and Tumor (GRANT) Score in Patients with Resected Renal Cell Carcinoma.Current urology · 2020Article
- Gender-Related Approach to Kidney Cancer Management: Moving Forward.International journal of molecular sciences · 2020Review
- Sex-specific analysis of renal cell carcinoma histology and survival in Japan: A population-based study 2004 to 2016.Health science reports · 2020Article
- Temporal Trends in Selecting Patients for Partial Nephrectomy for Small Renal Cell Carcinomas in Alberta, Canada.Research and reports in urology · 2020Article
- A Comprehensive Analysis of the Effect of Histological Subtypes on the Survival Probability of Kidney Carcinoma Patients: A Hypertabastic Survival Analysis.Journal of renal cancer · 2020Article
- Prognostic Molecular Signatures for Metastatic Potential in Clinically Low-Risk Stage I and II Clear Cell Renal Cell Carcinomas.Frontiers in oncology · 2020Article
- Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma.Frontiers in oncology · 2020Article
- Nomograms for predicting long-term overall survival and disease-specific survival of patients with clear cell renal cell carcinoma.OncoTargets and therapy · 2018Article
- Marital status and gender affect stage, tumor grade, treatment type and cancer specific mortality in TWorld journal of urology · 2017Article
- Gender differences in incidence and outcomes of urothelial and kidney cancer.Nature reviews. Urology · 2015Review
- Age-dependent association between sex and renal cell carcinoma mortality: a population-based analysis.Scientific reports · 2015Article
- Renal cell carcinoma in young patients: a review of recent literature.Current urology reports · 2015Review
- Associations between ABO blood groups and biochemical recurrence after radical prostatectomy.International journal of clinical and experimental medicine · 2015Article
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Authors and funding
30 authors at 11 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate gender differences in clinicopathological features and to analyze the prognostic impact of gender in renal cell carcinoma (RCC) patients undergoing surgery.
methodsA total of 6,234 patients (eleven centers; Europe and USA) treated by radical or partial nephrectomy were included in this retrospective study (median follow-up 59 months; IQR 30-106). Gender differences in clinicopathological parameters were assessed. Multivariable Cox regression models were applied to determine the influence of parameters on disease-specific survival (DSS) and overall survival (OS).
resultsA total of 3,751 patients of the study group were male patients (60.2 %), who were significantly younger at diagnosis and received more frequently NSS than women. Significantly, more often high-grade tumors and simultaneous metastasis were present in men. Whereas tumor size and pTN stages did not differ between genders, clear-cell and chromophobe RCC was diagnosed less frequently, but papillary RCC more often in men. Gender also independently influenced DSS (HR 0.75, p < 0.001) and OS (HR 0.80, p < 0.001) with a benefit for women. However, inclusion of gender in multivariable models did not significantly gain predictive accuracies (PA) for DSS (0.868-0.870, p = 0.628) and OS (0.775-0.777, p = 0.522). Furthermore, no significantly different DSS and OS rates were found in patients undergoing NSS.
conclusionsThis study demonstrates important gender differences in clinicopathological features and outcome of RCC patients with improved DSS and OS for women compared to men, even if solely patients with clear-cell RCC or M0-stage are taken into evaluation. However, inclusion of gender in multivariable models does not significantly gain PA of multivariable models.
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