ArticleHuman brain mapping2014
Diffusion weighted imaging of prefrontal cortex in prodromal Huntington's disease.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature.Brain and behavior · 2026Pooled it
- Prodromal Cognitive Changes as a Prognostic Indicator of Forthcoming Huntington's Disease Severity: A Retrospective Longitudinal Study.Movement disorders clinical practice · 2024Article
- Disentangling the neurobiological bases of temporal impulsivity in Huntington's disease.Brain and behavior · 2024Article
- Ex vivo 100 μm isotropic diffusion MRI-based tractography of connectivity changes in the end-stage R6/2 mouse model of Huntington's disease.Neuroprotection (Chichester, England) · 2023Article
- Neurophysiological hallmarks of Huntington's disease progression: an EEG and fMRI connectivity study.Frontiers in aging neuroscience · 2023Article
- Pain in Huntington's disease and its potential mechanisms.Frontiers in aging neuroscience · 2023Review
- Neuroimaging of Supraventricular Frontal White Matter in Children with Familial Attention-Deficit Hyperactivity Disorder and Attention-Deficit Hyperactivity Disorder Due to Prenatal Alcohol Exposure.Neurotoxicity research · 2021Article
- Moderate Intensity Exercise in Pre-manifest Huntington's Disease: Results of a 6 months Trial.SVOA neurology · 2021Article
- Time will tell: Decision making in premanifest and manifest Huntington's disease.Brain and behavior · 2020Article
- Diffusion imaging in Huntington's disease: comprehensive review.Journal of neurology, neurosurgery, and psychiatry · 2020Review
- A Critical Review of White Matter Changes in Huntington's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Review
- Detection of axonal degeneration in a mouse model of Huntington's disease: comparison between diffusion tensor imaging and anomalous diffusion metrics.Magma (New York, N.Y.) · 2019Article
- Genetic load determines atrophy in hand cortico-striatal pathways in presymptomatic Huntington's disease.Human brain mapping · 2018Article
- Natural biological variation of white matter microstructure is accentuated in Huntington's disease.Human brain mapping · 2018Article
- Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease.NeuroImage. Clinical · 2018Article
- Longitudinal diffusion changes in prodromal and early HD: Evidence of white-matter tract deterioration.Human brain mapping · 2017Article
- Cross-sectional and longitudinal multimodal structural imaging in prodromal Huntington's disease.Movement disorders : official journal of the Movement Disorder Society · 2016Article
- Joint reconstruction of white-matter pathways from longitudinal diffusion MRI data with anatomical priors.NeuroImage · 2016Article
- Major Superficial White Matter Abnormalities in Huntington's Disease.Frontiers in neuroscience · 2016Article
- Prefrontal cortex white matter tracts in prodromal Huntington disease.Human brain mapping · 2015Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Huntington's disease (HD) is a devastating neurodegenerative disease with no effective disease-modifying treatments. There is considerable interest in finding reliable indicators of disease progression to judge the efficacy of novel treatments that slow or stop disease onset before debilitating signs appear. Diffusion-weighted imaging (DWI) may provide a reliable marker of disease progression by characterizing diffusivity changes in white matter (WM) in individuals with prodromal HD. The prefrontal cortex (PFC) may play a role in HD progression due to its prominent striatal connections and documented role in executive function. This study uses DWI to characterize diffusivity in specific regions of PFC WM defined by FreeSurfer in 53 prodromal HD participants and 34 controls. Prodromal HD individuals were separated into three CAG-Age Product (CAP) groups (16 low, 22 medium, 15 high) that indexed baseline progression. Statistically significant increases in mean diffusivity (MD) and radial diffusivity (RD) among CAP groups relative to controls were seen in inferior and lateral PFC regions. For MD and RD, differences among controls and HD participants tracked with baseline disease progression. The smallest difference was for the low group and the largest for the high group. Significant correlations between Trail Making Test B (TMTB) and mean fractional anisotropy (FA) and/or RD paralleled group differences in mean MD and/or RD in several right hemisphere regions. The gradient of effects that tracked with CAP group suggests DWI may provide markers of disease progression in future longitudinal studies as increasing diffusivity abnormalities in the lateral PFC of prodromal HD individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.