Evidence map›Paper›PMID 23568369›Full record

ReviewPflugers Archiv : European journal of physiology2013

Multifaceted roles of STIM proteins.

Robert Hooper, Elsie Samakai, Joseph Kedra, Jonathan Soboloff

Abstract readReview
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Multifaceted control of T cell differentiation by STIM1.Trends in biochemical sciences · 2023
    Review
  4. Neuronal Store-Operated Calcium Channels.Molecular neurobiology · 2023
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. STIM1 Knockout Enhances PDGF-Mediated CaInternational journal of molecular sciences · 2018
    Article
  10. STIM1 (c)AMPs up melanogenesis.The EMBO journal · 2018
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Orai1 enhances muscle endurance by promoting fatigue-resistant type I fiber content but not through acute store-operated Ca2+ entry.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016
    Article
  16. Article
  17. Neuronal STIMulation at rest.Science signaling · 2014
    Review
  18. Membrane traffic research: challenges for the next decade.Frontiers in cell and developmental biology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert HooperDepartment of Biochemistry, Temple University School of Medicine, 3440 North Broad Street, Philadelphia, PA, 19140, USA.
Elsie Samakai
Joseph Kedra
Jonathan Soboloff

Funding

Modulation of calcium signaling by changes in STIM expressionR01GM097335 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI SOBOLOFF, JONATHAN A · 2011 to 2015
$1.5M
NIGMS NIH HHS GM097335NIGMS NIH HHS R01 GM097335
6 · The paper itself

Abstract

Stromal interaction molecules (STIM1 and STIM2) are critical components of store-operated calcium entry. Sensing depletion of endoplasmic reticulum (ER) Ca(2+) stores, STIM couples with plasma membrane Orai channels, resulting in the influx of Ca(2+) across the PM into the cytosol. Although best recognized for their primary role as ER Ca(2+) sensors, increasing evidence suggests that STIM proteins have a broader variety of sensory capabilities than first envisaged, reacting to cell stressors such as oxidative stress, temperature, and hypoxia. Further, the array of partners for STIM proteins is now understood to range far beyond the Orai channel family. Here we discuss the implications of STIM's expanding role, both as a stress sensor and a general modulator of multiple physiological processes in the cell.

Indexed as

Calcium SignalingAnimalsCalcium-Binding ProteinsHumansMembrane GlycoproteinsStress, PhysiologicalCalcium-Binding ProteinsMembrane Glycoproteins

Identifiers

PMID23568369
PMCPMC3758454

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.