ArticleJournal of the American Heart Association2013
The value of carotid artery plaque and intima-media thickness for incident cardiovascular disease: the multi-ethnic study of atherosclerosis.
Article in Journal of the American Heart Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01212900. Cited by 152 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The RIGHT Study: Risk Stratification With Image Guidance of HMG Coa Reductase Inhibitor Therapy
Open the trial in the graphWho cites it
152 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies.Arteriosclerosis, thrombosis, and vascular biology · 2024Pooled it
- A systematic review of the status and methodological considerations for estimating risk of first ever stroke in the general population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial.The lancet. Diabetes & endocrinology · 2017Trial
- The association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular disease.Blood pressure monitoring · 2017Trial
- Trial
- Edge-detected common carotid artery intima-media thickness and incident coronary heart disease in the multi-ethnic study of atherosclerosis.Journal of the American Heart Association · 2015Trial
- Multivariate adaptive regression spline modeling for estimating carotid artery plaque thickness in Chinese men with type 2 diabetes.The Journal of international medical research · 2026Article
- Review
- Increased Adiposity and Dyslipidemia in Young Men Living with HIV Compared to Matched PrEP Users: A Cross-Sectional Study.Advances in therapy · 2026Article
- Associations between phenotypic age and carotid atherosclerosis among the general population: evidence from a multi-stage study.BMC cardiovascular disorders · 2026Article
- Consensus machine learning identifies cell death gene signature for carotid artery stenosis diagnosis.iScience · 2026Article
- Endothelial BMP6 Drives Hemodynamic-Dependent VSMCs Calcification in Carotid Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Circulating vitamin D and follicle-stimulating hormone levels are associated with subclinical atherosclerosis in climacteric women with menopausal syndrome.Frontiers in endocrinology · 2026Article
- Risk Stratification and Coronary Optical Coherence Tomography Findings in Asymptomatic Patients With Type 1 Diabetes Mellitus.Physiological research · 2025Article
- Automated Deep Learning-Based Detection of Early Atherosclerotic Plaques in Carotid Ultrasound Imaging.medRxiv : the preprint server for health sciences · 2025Article
- Comprehensive analysis of risk factors associated with carotid plaque in patients with type 2 diabetes mellitus.World journal of diabetes · 2025Article
- Article
- Article
- Incidental Finding of Coronary and Non-Coronary Artery Calcium: What Do Clinicians Need To Know?Current atherosclerosis reports · 2025Review
- Carotid plaque score is associated with 10-year major adverse cardiovascular events in low-intermediate risk patients referred to a general cardiology community clinic.European heart journal. Cardiovascular Imaging · 2025Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundCarotid artery plaques are associated with coronary artery atherosclerotic lesions. We evaluated various ultrasound definitions of carotid artery plaque as predictors of future cardiovascular disease (CVD) and coronary heart disease (CHD) events. METHODS AND
resultsWe studied the risk factors and ultrasound measurements of the carotid arteries at baseline of 6562 members (mean age 61.1 years; 52.6% women) of the Multi-Ethnic Study of Atherosclerosis (MESA). ICA lesions were defined subjectively as >0% or ≥25% diameter narrowing, as continuous intima-media thickness (IMT) measurements (maximum IMT or the mean of the maximum IMT of 6 images) and using a 1.5-mm IMT cut point. Multivariable Cox proportional hazards models were used to estimate hazard ratios for incident CVD, CHD, and stroke. Harrell's C-statistics, Net Reclassification Improvement, and Integrated Discrimination Improvement were used to evaluate the incremental predictive value of plaque metrics. At 7.8-year mean follow-up, all plaque metrics significantly predicted CVD events (n=515) when added to Framingham risk factors. All except 1 metric improved the prediction of CHD (by C-statistic, Net Reclassification Improvement, and Integrated Discrimination Improvement. Mean of the maximum IMT had the highest NRI (7.0%; P=0.0003) with risk ratio of 1.43/mm; 95% CI 1.26-1.63) followed by maximum IMT with an NRI of 6.8% and risk ratio of 1.27 (95% CI 1.18-1.38).
conclusionUltrasound-derived plaque metrics independently predict cardiovascular events in our cohort and improve risk prediction for CHD events when added to Framingham risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.