Evidence map›Paper›PMID 23568228›Full record

Trial reportAIDS and behavior2013

A randomized controlled trial examining the efficacy of motivational counseling with observed therapy for antiretroviral therapy adherence.

Kathy Goggin, Mary M Gerkovich, Karen B Williams, Julie W Banderas, Delwyn Catley, Jannette Berkley-Patton, Glenn J Wagner, James Stanford, Sally Neville, Vinutha K Kumar and 2 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03331978 (A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans), which is not on this map. Cited by 26 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 9 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03331978 nacompletednot on this mapstarted 2018, after this paper: background citation

A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans

TypeinterventionalSponsorRANDRan2018 to 2021Enrolled306ConditionsHIV/AIDSArmsRise - Treatment Education
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 9 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Complex solutions for a complex problem: A meta-analysis of the efficacy of multiple-behavior interventions on change in outcomes related to HIV.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Kathy GogginHIV Research Group, Department of Psychology, University of Missouri-Kansas City, 5030 Cherry Street, Ste 310, Kansas City, MO 64110, USA. goggink@umkc.edu
Mary M Gerkovich
Karen B Williams
Julie W Banderas
Delwyn Catley
Jannette Berkley-Patton
Glenn J Wagner
James Stanford
Sally Neville
Vinutha K Kumar
David M Bamberger
Lisa A Clough
University of Missouri–Kansas City · USKansas City CARE Clinic · USKansas City VA Medical Center · USRAND Corporation · USUniversity of Kansas Medical Center · US

Funding

ART Adherence: Observed Therapy and Enhanced CounselingR01MH068197 · NIMH · UNIVERSITY OF MISSOURI KANSAS CITY · PI GOGGIN, KATHY J · 2004 to 2008
$3.6M
NIMH NIH HHS R01 MH068197
6 · The paper itself

Abstract

This study determined whether motivational interviewing-based cognitive behavioral therapy (MI-CBT) adherence counseling combined with modified directly observed therapy (MI-CBT/mDOT) is more effective than MI-CBT counseling alone or standard care (SC) in increasing adherence over time. A three-armed randomized controlled 48-week trial with continuous electronic drug monitored adherence was conducted by randomly assigning 204 HIV-positive participants to either 10 sessions of MI-CBT counseling with mDOT for 24 weeks, 10 sessions of MI-CBT counseling alone, or SC. Poisson mixed effects regression models revealed significant interaction effects of intervention over time on non-adherence defined as percent of doses not-taken (IRR = 1.011, CI = 1.000-1.018) and percent of doses not-taken on time (IRR = 1.006, CI = 1.001-1.011) in the 30 days preceding each assessment. There were no significant differences between groups, but trends were observed for the MI-CBT/mDOT group to have greater 12 week on-time and worse 48 week adherence than the SC group. Findings of modest to null impact on adherence despite intensive interventions highlights the need for more effective interventions to maintain high adherence over time.

Indexed as

Directly Observed TherapyMedication AdherenceMotivational InterviewingAdolescentAdultAgedAnti-HIV AgentsCognitive Behavioral TherapyFemaleHIV InfectionsHumansMaleMiddle AgedYoung AdultAnti-HIV Agents

Identifiers

PMID23568228
PMCPMC3672512
OpenAlexW2041505204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.