ArticleInternational journal of obesity (2005)2013
Parental obesity and risk factors for cardiovascular disease among their offspring in mid-life: findings from the 1958 British Birth Cohort Study.
Article in International journal of obesity (2005), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Family history of cardiovascular disease and its modifiable risk factors and association with offspring risk profile.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring.European heart journal · 2024Review
- Birth weight moderates the association between obesity and mortality rate.Annals of epidemiology · 2023Article
- Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring.The Proceedings of the Nutrition Society · 2022Review
- The association between general and central obesity and the risks of coronary heart disease in women with and without a familial predisposition to obesity: findings from the Danish Nurse Cohort.International journal of obesity (2005) · 2022Article
- Development and Validation of a Simple Risk Model for Predicting Metabolic Syndrome (MetS) in Midlife: A Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Article
- Early Determinants of Childhood Blood Pressure at the Age of 6 Years: The GECKO Drenthe and ABCD Study Birth Cohorts.Journal of the American Heart Association · 2020Article
- Anthropometric and cardiometabolic risk factors in parents and child obesity in Segamat, Malaysia.International journal of epidemiology · 2017Article
- Article
- The early life nutritional environment and early life stress as potential pathways towards the metabolic syndrome in mid-life? A lifecourse analysis using the 1958 British Birth cohort.BMC public health · 2016Article
- Transmission of energy-saving efficiency from obese parents to their offspring: the Korean National Health and Nutrition Examination Survey 2007-2011.European journal of clinical nutrition · 2016Article
- Relation of Cardiometabolic Risk Factors between Parents and Children.The Journal of pediatrics · 2015Article
- Parental weight status and offspring cardiovascular disease risks: a cross-sectional study of Chinese children.Preventing chronic disease · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFew studies have investigated whether parental adiposity is associated with offspring cardiovascular health or the underlying pathways. Studying these associations may help to illuminate the paradox of increasing prevalence of obesity and declining trends in cardiovascular disease (CVD) mortality, which may be partially explained by beneficial adaptations to an obesogenic environment among people exposed to such environments from younger ages.
objectiveTo investigate associations between parental body mass index (BMI) and risk factors for CVD among their offspring in mid-life and to test whether associations of offspring BMI with CVD risk factors were modified by parental BMI.
methodsData from parents and offspring in the 1958 British birth cohort were used (N=9328). Parental BMI was assessed when offspring were aged 11 years; offspring BMI, waist circumference and CVD risk factors (lipid levels, blood pressure, glycosylated haemoglobin (HbA1c) and inflammatory and haemostatic markers) were measured at 44-45 years.
resultsHigher parental BMI was associated with less favourable levels of offspring risk factors for CVD. Most associations were maintained after adjustment for offspring lifestyle and socioeconomic factors but were largely abolished or reversed after adjustment for offspring adiposity. For some CVD risk factors, there was evidence of effect modification; the association between higher BMI and an adverse lipid profile among offspring was weaker if maternal BMI had been higher. Conversely, offspring BMI was more strongly associated with HbA1c if parental BMI had been higher.
conclusionsIntergenerational influences may be important in conferring the effect of high BMI on CVD risk among offspring.
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