ArticleBiochimica et biophysica acta2013
Fibronectin conformation regulates the proangiogenic capability of tumor-associated adipogenic stromal cells.
Article in Biochimica et biophysica acta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Decellularized extracellular matrix-based disease models for drug screening.Materials today. Bio · 2024Review
- Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application.Bioactive materials · 2024Review
- Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity.Signal transduction and targeted therapy · 2021Review
- Fibronectin in Fracture Healing: Biological Mechanisms and Regenerative Avenues.Frontiers in bioengineering and biotechnology · 2021Review
- Collagen microarchitecture mechanically controls myofibroblast differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells.Journal of Cancer · 2020Article
- Mechanical and Physical Regulation of Fibroblast-Myofibroblast Transition: From Cellular Mechanoresponse to Tissue Pathology.Frontiers in bioengineering and biotechnology · 2020Review
- The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix.Journal of cell science · 2018Article
- Novel peptide probes to assess the tensional state of fibronectin fibers in cancer.Nature communications · 2017Article
- Breast cancer-derived extracellular vesicles stimulate myofibroblast differentiation and pro-angiogenic behavior of adipose stem cells.Matrix biology : journal of the International Society for Matrix Biology · 2017Article
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- Cooperative effects of fibronectin matrix assembly and initial cell-substrate adhesion strength in cellular self-assembly.Acta biomaterialia · 2016Article
- Utilizing Fibronectin Integrin-Binding Specificity to Control Cellular Responses.Advances in wound care · 2015Review
- 3D Conducting Polymer Platforms for Electrical Control of Protein Conformation and Cellular Functions.Journal of materials chemistry. B · 2015Article
- Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells.Biomaterials · 2015Article
- Effect of the Materials Properties of Hydroxyapatite Nanoparticles on Fibronectin Deposition and Conformation.Crystal growth & design · 2015Article
- In vitro models of tumor vessels and matrix: engineering approaches to investigate transport limitations and drug delivery in cancer.Advanced drug delivery reviews · 2014Review
- Heparin-dependent regulation of fibronectin matrix conformation.Matrix biology : journal of the International Society for Matrix Biology · 2014Article
- Fibronectin Mechanobiology Regulates Tumorigenesis.Cellular and molecular bioengineeringReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundChanges in fibronectin (Fn) matrix remodeling contribute to mammary tumor angiogenesis and are related to altered behavior of adipogenic stromal cells; yet, the underlying mechanisms remain unclear due in part to a lack of reductionist model systems that allow the inherent complexity of cell-derived extracellular matrices (ECMs) to be deciphered. In particular, breast cancer-associated adipogenic stromal cells not only enhance the composition, quantity, and rigidity of deposited Fn, but also partially unfold these matrices. However, the specific effect of Fn conformation on tumor angiogenesis is undefined.
methodsDecellularized matrices and a conducting polymer device consisting of poly(3,4-ethylenedioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS) were used to examine the effect of Fn conformation on the behavior of 3T3-L1 preadipocytes. Changes in cell adhesion and proangiogenic capability were tested via cell counting and by quantification of vascular endothelial growth factor (VEGF) secretion, respectively. Integrin-blocking antibodies were utilized to examine varied integrin specificity as a potential mechanism.
resultsOur findings suggest that tumor-associated partial unfolding of Fn decreases adhesion while enhancing VEGF secretion by breast cancer-associated adipogenic precursor cells, and that altered integrin specificity may underlie these changes. CONCLUSIONS AND GENERAL SIGNIFICANCE: These results not only have important implications for our understanding of tumorigenesis, but also enhance knowledge of cell-ECM interactions that may be harnessed for other applications including advanced tissue engineering approaches. This article is part of a Special Issue entitled Organic Bioelectronics - Novel Applications in Biomedicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.