ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2014
Perceived stress is associated with subclinical cerebrovascular disease in older adults.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.Frontiers in neurology · 2019Pooled it
- Adverse Social Exposome During the Life Course and Vascular Brain Injury.JAMA network open · 2025Article
- Psychosocial Stress and Risk for Intracerebral Hemorrhage in the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) Study.Journal of the American Heart Association · 2025Article
- The interplay of academic procrastination, self-generated stress, and self-reported bruxism among medical and dental students: a cross-sectional study.BMC psychology · 2024Article
- Racial and Socioeconomic Status among a Patient Population Presenting with Aneurysmal Subarachnoid Hemorrhage versus Unruptured Intracranial Aneurysm: A Single-Center Study.Brain sciences · 2024Article
- Association between Perceived Stress and Motoric Cognitive Risk Syndrome in an Elderly Population: Rugao Longevity and Aging Study.Dementia and geriatric cognitive disorders · 2024Article
- Stress and the brain: Emotional support mediates the association between myelination in the right supramarginal gyrus and perceived chronic stress.Neurobiology of stress · 2023Article
- Toxic Psychosocial Stress, Resiliency Resources and Time to Dementia Diagnosis in a Nationally Representative Sample of Older Americans in the Health and Retirement Study from 2006-2016.International journal of environmental research and public health · 2022Article
- In Older Adults, Perceived Stress and Self-Efficacy Are Associated with Verbal Fluency, Reasoning, and Prospective Memory (Moderated by Socioeconomic Position).Brain sciences · 2022Article
- Higher Perceived Stress as an Independent Predictor for Lower Use of Emotion-Focused Coping Strategies in Hypertensive Individuals.Frontiers in psychology · 2022Article
- Impact of Stress and Loneliness on Health-Related Quality of Life Among Low Income Senior African Americans.Journal of racial and ethnic health disparities · 2021Article
- The functional connectome predicts feeling of stress on regular days and during the COVID-19 pandemic.Neurobiology of stress · 2021Article
- Marital Status and Dementia: Evidence from the Health and Retirement Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020Article
- Lifetime discrimination burden, racial discrimination, and subclinical cerebrovascular disease among African Americans.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Article
- Perceived stress across the midlife: longitudinal changes among a diverse sample of women, the Study of Women's health Across the Nation (SWAN).Women's midlife health · 2018Article
- Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy.Journal of Alzheimer's disease reports · 2017Article
- Effects of stressful life events on cerebral white matter hyperintensity progression.International journal of geriatric psychiatry · 2017Article
- Perceived Stress and Cognitive Decline in Different Cognitive Domains in a Cohort of Older African Americans.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- Stroke Knowledge in African Americans: A Narrative Review.Ethnicity & disease · 2016Review
- The Association between Filial Piety and Perceived Stress among Chinese Older Adults in Greater Chicago Area.Journal of geriatrics and palliative care · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association of perceived stress with magnetic resonance imaging (MRI) markers of subclinical cerebrovascular disease in an elderly cohort.
methodsUsing a cross-sectional study of a community-based cohort in Chicago, 571 adults (57% women; 58.1% African American; 41.9% non-Hispanic white; mean [SD] age: 79.8 [5.9] years) from the Chicago Health and Aging Project, an epidemiologic study of aging, completed questionnaires on perceived stress, medical history, and demographics as part of an in-home assessment and 5 years later underwent a clinical neurologic examination and MRI of the brain. Outcome measures were volumetric MRI assessments of white matter hyperintensity volume (WMHV), total brain volume (TBV), and cerebral infarction.
resultsStress was measured with six items from the Perceived Stress Scale (PSS); item responses, ranging from never (0) to often (3), were summed to create an overall stress score (mean [SD]: 4.9 [3.3]; range: 0-18). Most participants had some evidence of vascular disease on MRI, with 153 participants (26.8%) having infarctions. In separate linear and logistic regression models adjusted for age, sex, education, race, and time between stress assessment and MRI, each one-point increase in PSS score was associated with significantly lower TBV (coefficient = -0.111, SE = 0.049, t[563] = -2.28, p = 0.023) and 7% greater odds of infarction (odds ratio: 1.07; 95% confidence interval: 1.01, 1.13; Wald χ(2)[1] = 4.90; p = 0.027). PSS scores were unrelated to WMHV. Results were unchanged with further adjustment for smoking, body mass index, physical activity, history of heart disease, stroke, diabetes, hypertension, depressive symptoms, and dementia.
conclusionsGreater perceived stress was significantly and independently associated with cerebral infarction and lower brain volume assessed 5 years later in this elderly cohort.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.