ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2014
Depressive symptoms and circadian activity rhythm disturbances in community-dwelling older women.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- The Role of Digital Biomarkers in Physiological Signal-Based Depression Assessment: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Depressive symptom screening in elderly by passive sensing data of smartphones or smartwatches: A systematic review.PloS one · 2024Pooled it
- Circadian Preference as a Moderator of Depression Outcome Following Cognitive Behavioral Therapy for Insomnia Plus Antidepressant Medications: A Report From the TRIAD Study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Trial
- A rest-activity biomarker to predict response to SSRIs in major depressive disorder.Journal of psychiatric research · 2015Trial
- Explainable AI for Depression Detection and Severity Classification From Activity Data: Development and Evaluation Study of an Interpretable Framework.JMIR mental health · 2025Article
- Rest-activity rhythm phenotypes in adults with epilepsy and intellectual disability.Epilepsia open · 2025Article
- Rest-Activity Rhythm Patterns and Their Associations With Depression and Obesity: A Study Using Actigraphy and Human-Smartphone Interactions.Depression and anxiety · 2025Article
- Sleep Deficiency in Obstructive Sleep Apnea.Sleep medicine clinics · 2024Review
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- Sleep Deficiency in Obstructive Sleep Apnea.Clinics in chest medicine · 2022Review
- Sleep Deficiency in the Elderly.Clinics in chest medicine · 2022Review
- Digital Biomarkers for Depression Screening With Wearable Devices: Cross-sectional Study With Machine Learning Modeling.JMIR mHealth and uHealth · 2021Article
- Screening for Depression in Daily Life: Development and External Validation of a Prediction Model Based on Actigraphy and Experience Sampling Method.Journal of medical Internet research · 2020Article
- Level and timing of physical activity during normal daily life in depressed and non-depressed individuals.Translational psychiatry · 2020Article
- Characterizing Behavioral Activity Rhythms in Older Adults Using Actigraphy.Sensors (Basel, Switzerland) · 2020Review
- Assessment of Circadian Rhythms.Neurologic clinics · 2019Review
- The effect of night shift on sleep quality and depressive symptoms among Chinese nurses.Neuropsychiatric disease and treatment · 2019Article
- Impact of Poor Sleep on Physical and Mental Health in Older Women.Sleep medicine clinics · 2018Review
- Rest-activity rhythm profiles associated with manic-hypomanic and depressive symptoms.Journal of psychiatric research · 2018Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesAging is associated with changes in circadian rhythms. Current evidence supports a role for circadian rhythms in the pathophysiology of depression. However, little is known about the relationship between depressive symptoms and circadian activity rhythms in older adults. We examined this association in community-dwelling older women.
methodsWe performed a cross-sectional analysis of 3,020 women (mean age: 83.55 ± 3.79 years) enrolled in the Study of Osteoporotic Fractures. Depressive symptoms were assessed with the Geriatric Depression Scale categorizing participants as "normal" (0-2; referent group, N = 1,961), "some depressive symptoms" (3-5, N = 704), or "depressed" (≥6, N = 355). Circadian activity rhythm variables were measured using wrist actigraphy.
resultsIn age-adjusted and Study of Osteoporotic Fractures site-adjusted models, greater levels of depressive symptoms were associated with decreased amplitude (height; df = 3,014, t = -11.31, p for linear trend <0.001), pseudo F-statistic (robustness; df = 3,014, t = -8.07, p for linear trend <0.001), and mesor (mean modeled activity; df = 3014, t = -10.36, p for linear trend <0.001) of circadian activity rhythms. Greater levels of depressive symptoms were also associated with increased odds of being in the lowest quartile for amplitude (df = 1, χ(2) = 9240, p for linear trend <0.001), pseudo F-statistic (df = 1, χ(2) = 49.73, p for linear trend <0.001), and mesor (df = 1, χ(2) = 81.12, p for linear trend <0.001). These associations remained significant in multivariate models. Post-hoc analyses comparing mean amplitude, mesor, and pseudo F-statistic values pair-wise between depression-level groups revealed significant differences between women with "some depressive symptoms" and the "normal" group.
conclusionThese data suggest a graded association between greater levels of depressive symptoms and more desynchronization of circadian activity rhythms in community-dwelling older women. This association was observed even for women endorsing subthreshold levels of depressive symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.