Evidence map›Paper›PMID 23567406›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2013

Are depression and frailty overlapping syndromes in mid- and late-life? A latent variable analysis.

Briana Mezuk, Matthew Lohman, Levent Dumenci, Kate L Lapane

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Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  3. Depression and frailty in later life: a systematic review.Clinical interventions in aging · 2015
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Briana MezukDepartment of Epidemiology and Community Health, Virginia Commonwealth University School of Medicine, Richmond. Electronic address: bmezuk@vcu.edu.
Matthew Lohman
Levent Dumenci
Kate L Lapane

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR031990 · NCRR · VIRGINIA COMMONWEALTH UNIVERSITY · PI CLORE, JOHN N. · 2010 to 2011
$7.7M
EVOLUTION OF PSYCHOPATHOLOGY IN THE POPULATIONR01MH047447 · NIMH · JOHNS HOPKINS UNIVERSITY · PI EATON, WILLIAM W · 1992 to 2006
$5.3M
VCU Building Interdisciplinary Research Careers in Women's HealthK12HD055881 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI STRAUSS, JEROME F · 2007 to 2011
$2.5M
Evolution of Psychopathology in the PopulationR01DA026652 · NIDA · JOHNS HOPKINS UNIVERSITY · PI EATON, WILLIAM W · 2009 to 2013
$2.4M
Depression, inflammation, and diabetes: Exploring shared etiopathologyK01MH093642 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI MEZUK, BRIANA · 2012 to 2015
$689k
Integrating multisource data on youth psychopathologyR03MH064474 · NIMH · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI DUMENCI, LEVENT · 2003 to 2004
$152k
NCRR NIH HHS UL1 RR031990NCRR NIH HHS UL1RR031990NICHD NIH HHS K12 HD055881NICHD NIH HHS K12-HD055881NIDA NIH HHS R01 DA026652NIDA NIH HHS R01-DA026652NIMH NIH HHS K01 MH093642NIMH NIH HHS R01 MH047447NIMH NIH HHS R03 MH064474NIMH NIH HHS R03-MH64474
6 · The paper itself

Abstract

backgroundDepression and frailty both predict disability and morbidity in later life. However, it is unclear to what extent these common geriatric syndromes represent overlapping constructs.

objectiveTo examine the joint relationship between the constructs of depression and frailty.

methodsData come from 2004-2005 wave of the Baltimore Epidemiologic Catchment Area Study, and the analysis is limited to participants 40 years and older, with complete data on frailty and depression indicators (N = 683). Depression was measured using the Diagnostic Interview Schedule, and frailty was indexed by modified Fried criteria. A series of confirmatory latent class analyses were used to assess the degree to which depression and frailty syndromes identify the same populations. A latent kappa coefficient (κl) was also estimated between the constructs.

resultsConfirmatory latent class analyses indicated that depression and frailty represent distinct syndromes rather than a single construct. The joint modeling of the two constructs supported a three-class solution for depression and two-class solution for frailty, with 2.9% categorized as severely depressed, 19.4% as mildly depressed, and 77.7% as not depressed, and 21.1% categorized as frail and 78.9% as not frail. The chance-corrected agreement statistic indicated moderate correspondence between the depression and frailty constructs (κl: 66, 95% confidence interval: 0.58-0.74).

conclusionsResults suggest that depression and frailty are interrelated concepts, yet their operational criteria identify substantively overlapping subpopulations. These findings have implications for understanding factors that contribute to the etiology and prognosis of depression and frailty in later life.

Indexed as

AdultAgedAged, 80 and overAgingBaltimoreDepressionFrail ElderlyHumansMaleMiddle AgedModels, StatisticalSyndrome

Identifiers

PMID23567406
PMCPMC3424389

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.