ArticleDevelopmental and comparative immunology2013
Developmental progression of equine immunoglobulin heavy chain variable region diversity.
Article in Developmental and comparative immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Identification of gene conversion events in horse IGHV suggests preferential hotspots for diversification.Immunogenetics · 2026Article
- ExploitingViruses · 2022Article
- Transcriptome analysis of immune genes in peripheral blood mononuclear cells of young foals and adult horses.PloS one · 2018Article
- Developmental expression of B cell molecules in equine lymphoid tissues.Veterinary immunology and immunopathology · 2017Article
- Antigen-specific immunoglobulin variable region sequencing measures humoral immune response to vaccination in the equine neonate.PloS one · 2017Article
- Article
- Applied Protein and Molecular Techniques for Characterization of B Cell Neoplasms in Horses.Clinical and vaccine immunology : CVI · 2015Article
- Hematopoiesis in the equine fetal liver suggests immune preparedness.Immunogenetics · 2014Article
- Diversity of immunoglobulin lambda light chain gene usage over developmental stages in the horse.Developmental and comparative immunology · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Humoral immunity is a critical component of the immune system that is established during fetal life and expands upon exposure to pathogens. The extensive humoral immune response repertoire is generated in large part via immunoglobulin (Ig) heavy chain variable region diversity. The horse is a useful model to study the development of humoral diversity because the placenta does not transfer maternal antibodies; therefore, Igs detected in the fetus and pre-suckle neonate were generated in utero. The goal of this study was to compare the equine fetal Ig VDJ repertoire to that of neonatal, foal, and adult horse stages of life. We found similar profiles of IGHV, IGHD, and IGHJ gene usage throughout life, including predominant usage of IGHV2S3, IGHD18S1, and IGHJ1S5. CDR3H lengths were also comparable throughout life. Unexpectedly, Ig sequence diversity significantly increased between the fetal and neonatal age, and, as expected, between the foal and adult age.
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Registered trials
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