ReviewNature reviews. Gastroenterology & hepatology2013
Tumour progression and liver regeneration--insights from animal models.
Review in Nature reviews. Gastroenterology & hepatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- The combination of extra-Glissonian pedicle ligation of the tumor-bearing area and traditional ALPPS: a novel modified ALPPS method.Journal of gastrointestinal oncology · 2025Article
- Modelling the impact of liver regeneration on hepatoblastoma patient-derived-xenograft tumor growth.Pediatric research · 2024Article
- The role of ischaemia-reperfusion injury and liver regeneration in hepatic tumour recurrence.JHEP reports : innovation in hepatology · 2023Review
- MDIG-mediated H3K9me3 demethylation upregulates Myc by activating OTX2 and facilitates liver regeneration.Signal transduction and targeted therapy · 2023Article
- Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma.Nature communications · 2023Article
- Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis.Cell death & disease · 2023Article
- Imaging-guided interventions modulating portal venous flow: Evidence and controversies.JHEP reports : innovation in hepatology · 2022Review
- Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment.Cell death & disease · 2022Article
- Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2022Article
- Simultaneous colorectal and parenchymal-sparing liver resection for advanced colorectal carcinoma with synchronous liver metastases: Between conventional and mini-invasive approaches.World journal of gastroenterology · 2020Review
- Simultaneous curative resection of double colorectal carcinoma with synchronous bilobar liver metastases.World journal of gastrointestinal oncology · 2018Review
- In situ splitting after selective partial portal vein ligation or simultaneous hepatic artery ligation promotes liver regeneration.Scientific reports · 2018Article
- Role of Kupffer cells in the progression of CRC liver metastases after the first stage of ALPPS.Scientific reports · 2018Article
- Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway.Cell death & disease · 2018Article
- HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis.The Journal of clinical investigation · 2018Article
- Next generation sequencing of progressive colorectal liver metastases after portal vein embolization.Clinical & experimental metastasis · 2017Article
- Liver regeneration microenvironment of hepatocellular carcinoma for prevention and therapy.Oncotarget · 2017Review
- A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells.Oncotarget · 2016Article
- Parenchymal-sparing liver surgery in patients with colorectal carcinoma liver metastases.World journal of gastrointestinal surgery · 2016Review
- Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.Nature cell biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgery remains the only curative treatment for colorectal liver metastases. For patients with multiple bilobar spread, extended hepatectomy might be required to achieve complete margin-free resection. In such cases, portal vein occlusion has been developed to induce preoperative hypertrophy of the future remnant liver and increase the resectability rate. Evidence now suggests that liver regeneration after hepatectomy and portal vein occlusion has a protumorigenic role, either through an upregulation of growth factors and cytokines or by haemodynamic changes in the blood supply to the liver. Experimental studies have reported a stimulatory effect of liver regeneration on the tumoral volume of liver metastases and on the metastatic potential of cells engrafted in the liver; this effect seems to depend on the timing of hepatectomy and portal vein occlusion. However, the variability of animal tumour models that are used for research in experimental colorectal liver metastases might account for some of the inconsistent and conflicting results. This Review presents clinical and experimental data pertaining to whether liver regeneration causes proliferation of tumour cells. We also analyse the different animal models of colorectal liver metastases in use and discuss current controversies in the field.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.