ArticleNeurobiology of learning and memory2013
Updating of action-outcome associations is prevented by inactivation of the posterior pedunculopontine tegmental nucleus.
Article in Neurobiology of learning and memory, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Midbrain endocannabinoids actuate dopamine-based action selection.Cell reports · 2026Article
- The Basal Ganglia and Mesencephalic Locomotor Region Connectivity Matrix.Current neuropharmacology · 2024Review
- Inhibition of midbrain cholinergic neurons impairs decision-making strategies during reversal learning.Frontiers in molecular neuroscience · 2024Article
- Inhibitory Pedunculopontine Neurons Gate Dopamine-Mediated Motor Actions of Unsigned Valence.Current neuropharmacology · 2024Article
- Advances in the study of cholinergic circuits in the central nervous system.Annals of clinical and translational neurology · 2023Review
- Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility.Trends in neurosciences · 2022Article
- Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies.Nature communications · 2020Article
- Microinjection of urotensin II into the pedunculopontine tegmentum leads to an increase in the consumption of sweet tastants.Physiology & behavior · 2020Article
- Dichotomy between motor and cognitive functions of midbrain cholinergic neurons.Neurobiology of disease · 2019Review
- Article
- Structural and functional considerations of the cholinergic brainstem.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Pedunculopontine tegmental nucleus lesions impair probabilistic reversal learning by reducing sensitivity to positive reward feedback.Neurobiology of learning and memory · 2016Article
- The pedunculopontine tegmental nucleus-A functional hypothesis from the comparative literature.Movement disorders : official journal of the Movement Disorder Society · 2016Review
- Reward and Behavioral Factors Contributing to the Tonic Activity of Monkey Pedunculopontine Tegmental Nucleus Neurons during Saccade Tasks.Frontiers in systems neuroscience · 2016Article
- Intra-ventral tegmental area microinjections of urotensin II modulate the effects of cocaine.Behavioural brain research · 2015Article
- Enhanced consumption of salient solutions following pedunculopontine tegmental lesions.Neuroscience · 2015Article
- Pedunculopontine tegmental nucleus neurons provide reward, sensorimotor, and alerting signals to midbrain dopamine neurons.Neuroscience · 2014Article
- The role of pedunculopontine nucleus in choice behavior under risk.The European journal of neuroscience · 2014Article
- Activity in mouse pedunculopontine tegmental nucleus reflects action and outcome in a decision-making task.Journal of neurophysiology · 2013Article
Corrections and comments
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3 authors at 2 institutions in 1 country.
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Abstract
The pedunculopontine tegmental nucleus (PPTg) is in a pivotal position between the basal ganglia and brainstem: it is able to influence and regulate all levels of basal ganglia and corticostriatal activity as well as being a key component of brainstem reticular and motor control circuitry. Consistent with its anatomical position, the PPTg has previously been shown to process rapid, salient sensory input, is a target for Parkinson's disease treatments and has been implicated in associative learning. We explicitly investigated the role of the posterior pPPTg (pPPTg) in action-outcome processes, where actions are performed with the goal-directed aim of obtaining an anticipated outcome. We assessed rats' sensitivity to degradation of the contingency between actions (lever pressing) and outcomes (food reward) during either inactivation of pPPTg by microinjection of the GABA agonist muscimol or control infusions of saline. In response to the degradation of contingency between lever press and food reward, saline treated rats rapidly reduced rates of lever pressing whereas muscimol treated rats (pPPTg inactivation) maintained previous lever pressing rates. In contrast, when the contingency between lever press and food reward was unchanged saline and muscimol treated rats maintained their previous rates of lever pressing. This shows that the pPPTg is critically required for updating associations between actions and outcomes, but not in the continued performance of previously learned associations. These results are consistent with a role for the PPTg in 'higher-order' associative learning and are the first to demonstrate a brainstem role in action-outcome learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.