ArticleNeurobiology of learning and memory2013
An Aplysia Egr homolog is rapidly and persistently regulated by long-term sensitization training.
Article in Neurobiology of learning and memory, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Transcriptional Changes Fade Prior to Long-Term Memory for Sensitization of thebioRxiv : the preprint server for biology · 2025Article
- ELAV Proteins Bind and Stabilize C/EBP mRNA in the Induction of Long-Term Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Immediate early genes in social insects: a tool to identify brain regions involved in complex behaviors and molecular processes underlying neuroplasticity.Cellular and molecular life sciences : CMLS · 2019Review
- Transcriptional changes before and after forgetting of a long-term sensitization memory in Aplysia californica.Neurobiology of learning and memory · 2018Article
- Transcriptional correlates of memory maintenance following long-term sensitization ofLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Npas4: Linking Neuronal Activity to Memory.Trends in neurosciences · 2016Review
- Characterization of the rapid transcriptional response to long-term sensitization training in Aplysia californica.Neurobiology of learning and memory · 2014Article
- Immediate and persistent transcriptional correlates of long-term sensitization training at different CNS loci in Aplysia californica.PloS one · 2014Article
- Article
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Authors and funding
6 authors.
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Abstract
The Egr family of transcription factors plays a key role in long-term plasticity and memory in a number of vertebrate species. Here we identify and characterize ApEgr (GenBank: KC608221), an Egr homolog in the marine mollusk Aplysia californica. ApEgr codes for a predicted 593-amino acid protein with the highly conserved trio of zinc-fingered domains in the C-terminus that characterizes the Egr family of transcription factors. Promoter analysis shows that the ApEgr protein selectively recognizes the GSG motif recognized by vertebrate Egrs. Like mammalian Egrs, ApEgr is constitutively expressed in a range of tissues, including the CNS. Moreover, expression of ApEgr is bi-directionally regulated by changes in neural activity. Of most interest, the association between ApEgr function and memory may be conserved in Aplysia, as we observe rapid and long-lasting up-regulation of expression after long-term sensitization training. Taken together, our results suggest that Egrs may have memory functions that are conserved from mammals to mollusks.
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