ReviewJournal of the mechanical behavior of biomedical materials2014
Mechanical forces in cerebral cortical folding: a review of measurements and models.
Review in Journal of the mechanical behavior of biomedical materials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortical Gyrification Morphology in Individuals with ASD and ADHD across the Lifespan: A Systematic Review and Meta-Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2021Pooled it
- A Mechanical Theory for the Formation of Short Association Fibers in the Brain.bioRxiv : the preprint server for biology · 2026Article
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A subject-specific reversible folding model reveals geometry-driven white-matter organization.bioRxiv : the preprint server for biology · 2025Article
- Astrocytes in white matter respond to tensile cues during cortical folding: a numerical study.bioRxiv : the preprint server for biology · 2025Article
- Typical development of the human fetal subplate: regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.bioRxiv : the preprint server for biology · 2025Article
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Feedback-Driven Dynamical Model for Axonal Extension on Parallel Micropatterns.Biomimetics (Basel, Switzerland) · 2025Article
- Experimental Measurement and Mathematical Quantification of Fixed-Charged Density in Rat and Pig Brain Tissue.Annals of biomedical engineering · 2025Article
- Characterization of the Porcine Cingulate Sulcus Cytoarchitecture.The Journal of comparative neurology · 2025Article
- Stress landscape of folding brain serves as a map for axonal pathfinding.Nature communications · 2025Article
- Article
- The Control of Cortical Folding: Multiple Mechanisms, Multiple Models.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Shining Light in Mechanobiology: Optical Tweezers, Scissors, and Beyond.ACS photonics · 2024Review
- Region-Dependent Mechanical Properties of Human Brain Tissue Under Large Deformations Using Inverse Finite Element Modeling.Annals of biomedical engineering · 2024Article
- The Fractal Geometry of the Human Brain: An Evolutionary Perspective.Advances in neurobiology · 2024Article
- Multi-scale measurement of stiffness in the developing ferret brain.Scientific reports · 2023Article
- Mechanical hierarchy in the formation and modulation of cortical folding patterns.Scientific reports · 2023Article
- An integrated finite element method and machine learning algorithm for brain morphology prediction.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates.Developmental cognitive neuroscience · 2023Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Folding of the cerebral cortical surface is a critical process in human brain development, yet despite decades of indirect study and speculation the mechanics of the process remain incompletely understood. Leading hypotheses have focused on the roles of circumferential expansion of the cortex, radial growth, and internal tension in neuronal fibers (axons). In this article, we review advances in the mathematical modeling of growth and morphogenesis and new experimental data, which together promise to clarify the mechanical basis of cortical folding. Recent experimental studies have illuminated not only the fundamental cellular and molecular processes underlying cortical development, but also the stress state and mechanical behavior of the developing brain. The combination of mathematical modeling and biomechanical data provides a means to evaluate hypothesized mechanisms objectively and quantitatively, and to ensure that they are consistent with physical law, given plausible assumptions and reasonable parameter values.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.