ArticleSchizophrenia research2013
Transmembrane AMPA receptor regulatory protein (TARP) dysregulation in anterior cingulate cortex in schizophrenia.
Article in Schizophrenia research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Preclinical Pharmacology of CX1837, a High-Impact Ampakine with an Improved Safety Margin: Implications for Treating Alzheimer's Disease and Ischemic Stroke.Current Alzheimer research · 2024Article
- Temporal Cortex Microarray Analysis Revealed Impaired Ribosomal Biogenesis and Hyperactivity of the Glutamatergic System: An Early Signature of Asymptomatic Alzheimer's Disease.Frontiers in neuroscience · 2022Article
- Structure and desensitization of AMPA receptor complexes with type II TARP γ5 and GSG1L.Molecular cell · 2021Article
- Polygenic Panels Predicting the Susceptibility of Multiple Upper Aerodigestive Tract Cancer in Oral Cancer Patients.Journal of personalized medicine · 2021Article
- Aberrant alternative splicing ofHeliyon · 2020Article
- Adenosine Kinase Expression in the Frontal Cortex in Schizophrenia.Schizophrenia bulletin · 2020Article
- Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects.Molecular psychiatry · 2020Article
- Cell-subtype-specific changes in adenosine pathways in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Dendritic structural plasticity and neuropsychiatric disease.Nature reviews. Neuroscience · 2018Review
- Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.Schizophrenia research · 2016Article
- Evaluation of voltage-dependent calcium channel γ gene families identified several novel potential susceptible genes to schizophrenia.Scientific reports · 2016Article
- Decreased synaptic and mitochondrial density in the postmortem anterior cingulate cortex in schizophrenia.Schizophrenia research · 2015Article
- Abnormal N-acetylglucosaminyltransferase expression in prefrontal cortex in schizophrenia.Schizophrenia research · 2015Article
- Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia.PloS one · 2015Article
- The frontoparietal control system: a central role in mental health.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Increased G protein-coupled receptor kinase (GRK) expression in the anterior cingulate cortex in schizophrenia.Schizophrenia research · 2014Article
- The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice.Molecular and cellular neurosciences · 2014Article
- Coherent somatic mutation in autoimmune disease.PloS one · 2014Review
- Evolutionarily conserved pattern of AMPA receptor subunit glycosylation in Mammalian frontal cortex.PloS one · 2014Article
- N-linked glycosylation of cortical N-methyl-D-aspartate and kainate receptor subunits in schizophrenia.Neuroreport · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The glutamate hypothesis of schizophrenia proposes that abnormal glutamatergic neurotransmission occurs in this illness, and a major contribution may involve dysregulation of the AMPA subtype of ionotropic glutamate receptor (AMPAR). Transmembrane AMPAR regulatory proteins (TARPs) form direct associations with AMPARs to modulate the trafficking and biophysical functions of these receptors, and their dysregulation may alter the localization and activity of AMPARs, thus having a potential role in the pathophysiology of schizophrenia. We performed comparative quantitative real-time PCR and Western blot analysis to measure transcript (schizophrenia, N=25; comparison subjects, N=25) and protein (schizophrenia, N=36; comparison subjects, N=33) expression of TARPs (γ subunits 1-8) in the anterior cingulate cortex (ACC) in schizophrenia and a comparison group. TARP expression was also measured in frontal cortex of rats chronically treated with haloperidol decanoate (28.5mg/kg every three weeks for nine months) to determine the effect of antipsychotic treatment on the expression of these molecules. We found decreased transcript expression of TARP γ-8 in schizophrenia. At the protein level, γ-3 and γ-5 were increased, while γ-4, γ-7 and γ-8 were decreased in schizophrenia. No changes in any of the molecules were noted in the frontal cortex of haloperidol-treated rats. TARPs are abnormally expressed at transcript and protein levels in ACC in schizophrenia, and these changes are likely due to the illness and not to the antipsychotic treatment. Alterations in the expression of TARPs may contribute to the pathophysiology of schizophrenia, and represent a potential mechanism of glutamatergic dysregulation in this illness.
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Registered trials
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