ArticleCurrent opinion in biotechnology2013
The details in the distributions: why and how to study phenotypic variability.
Article in Current opinion in biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 120 citations in OpenAlex.
- Experimental dissection of phenotypic variation for quantitative disease resistance in canola (Brassica napus) - Leptosphaeria maculans interactions.Pest management science · 2026Article
- Twenty-Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology.Yeast (Chichester, England) · 2026Review
- SIEVEseq: unified differential expression, variability, and skewness analyses using RNA-Seq data.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026Article
- Inter-individual gene expression variability implies stable regulation of brain-biased genes across organs in three ray-finned fishes.bioRxiv : the preprint server for biology · 2026Article
- Single-cell heterogeneity in ribosome content and the consequences for the growth laws.bioRxiv : the preprint server for biology · 2024Article
- Root plasticity improves maize nitrogen use when nitrogen is limiting: an analysis using 3D plant modelling.Journal of experimental botany · 2024Article
- Developmental noise and phenotypic plasticity are correlated inEvolution letters · 2024Article
- Detecting genetic effects on phenotype variability to capture gene-by-environment interactions: a systematic method comparison.G3 (Bethesda, Md.) · 2024Review
- Application of unimodal probability distribution models for morphological phenotyping of budding yeast.FEMS yeast research · 2024Article
- Acute stress reduces population-level metabolic and proteomic variation.BMC bioinformatics · 2023Article
- Article
- Parental ecological history can differentially modulate parental age effects on offspring physiological traits inCurrent zoology · 2022Article
- Evaluation of the phenotypic and genomic background of variability based on litter size of Large White pigs.Genetics, selection, evolution : GSE · 2022Article
- Single-cell image analysis to explore cell-to-cell heterogeneity in isogenic populations.Cell systems · 2021Review
- Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments.Analytical chemistry · 2021Article
- Developmental stochasticity and variation in floral phyllotaxis.Journal of plant research · 2021Review
- High-Throughput Live Imaging of Microcolonies to Measure Heterogeneity in Growth and Gene Expression.Journal of visualized experiments : JoVE · 2021Article
- Variation and Variability inFrontiers in behavioral neuroscience · 2021Article
- Heritable gene expression variability and stochasticity govern clonal heterogeneity in circadian period.PLoS biology · 2020Article
- FEATURE SELECTION FOR GENERALIZED VARYING COEFFICIENT MIXED-EFFECT MODELS WITH APPLICATION TO OBESITY GWAS.The annals of applied statistics · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Phenotypic variability is present even when genetic and environmental differences between cells are reduced to the greatest possible extent. For example, genetically identical bacteria display differing levels of resistance to antibiotics, clonal yeast populations demonstrate morphological and growth-rate heterogeneity, and mouse blastomeres from the same embryo have stochastic differences in gene expression. However, the distributions of phenotypes present among isogenic organisms are often overlooked; instead, many studies focus on population aggregates such as the mean. The details of these distributions are relevant to major questions in diverse fields, including the evolution of antimicrobial-drug and chemotherapy resistance. We review emerging experimental and statistical techniques that allow rigorous analysis of phenotypic variability and thereby may lead to advances across the biological sciences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.