Trial reportNeurogastroenterology and motility2013
Differences in brain responses between lean and obese women to a sweetened drink.
Trial report in Neurogastroenterology and motility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Pooled it
- Pooled it
- Effect of MIND diet intervention on cognitive performance and brain structure in healthy obese women: a randomized controlled trial.Scientific reports · 2022Trial
- Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.Scientific reports · 2021Trial
- Trial
- Humans with obesity have disordered brain responses to food images during physiological hyperglycemia.American journal of physiology. Endocrinology and metabolism · 2018Trial
- Running Performance With Nutritive and Nonnutritive Sweetened Mouth Rinses.International journal of sports physiology and performance · 2017Trial
- Influence of sucrose ingestion on brainstem and hypothalamic intrinsic oscillations in lean and obese women.Gastroenterology · 2014Trial
- Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation.Nature metabolism · 2025Article
- Machine learning model to predict obesity using gut metabolite and brain microstructure data.Scientific reports · 2023Article
- Food cue reactivity: Neurobiological and behavioral underpinnings.Reviews in endocrine & metabolic disorders · 2022Review
- Decreased excitability of leptin-sensitive anterior insula pyramidal neurons in a rat model of compulsive food demand.Neuropharmacology · 2022Article
- Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats.Nutrients · 2021Article
- Considering Sex as a Biological Variable in Basic and Clinical Studies: An Endocrine Society Scientific Statement.Endocrine reviews · 2021Article
- Article
- History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity.Obesity science & practice · 2019Article
- Brain Imaging of Taste Perception in Obesity: a Review.Current nutrition reports · 2019Review
- Obesity, body weight regulation and the brain: insights from fMRI.The British journal of radiology · 2018Article
- Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects.PloS one · 2018Article
- Sex differences in the influence of body mass index on anatomical architecture of brain networks.International journal of obesity (2005) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIngestion of sweet food is driven by central reward circuits and restrained by endocrine and neurocrine satiety signals. The specific influence of sucrose intake on central affective and reward circuitry and alterations of these mechanisms in the obese are incompletely understood. For this, we hypothesized that (i) similar brain regions are engaged by the stimulation of sweet taste receptors by sucrose and by non-nutrient sweeteners and (ii) during visual food-related cues, obese subjects show greater brain responses to sucrose compared with lean controls.
methodsIn a double-blind, crossover design, 10 obese and 10 lean healthy females received a sucrose or a non-nutrient sweetened beverage prior to viewing food or neutral images. BOLD signal was measured using a 1.5 Tesla MRI scanner. KEY
resultsViewing food images after ingestion of either drink was associated with engagement of similar brain regions (amygdala, hippocampus, thalamus, anterior insula). Obese differed from lean subjects in behavioral and brain responses rating both beverages as less tasteful and satisfying, yet demonstrating greater brain responses. Obese subjects also showed engagement of an additional brain network (including anterior insula, anterior cingulate, hippocampus, and amygdala) only after sucrose ingestion. CONCLUSIONS & INFERENCES: Obese subjects had a reduced behavioral hedonic response, yet a greater engagement of affective brain networks, particularly after sucrose ingestion, suggesting that in obese subjects, lingual and gut-derived signaling generate less central hedonic effects than food-related memories in response to visual cues, analogous to response patterns implicated in food addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.