ArticleScandinavian journal of trauma, resuscitation and emergency medicine2013
The prognostic value of gray-white-matter ratio in cardiac arrest patients treated with hypothermia.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Prognostic value of machine learning for brain computed tomography as a predictor of neurologic outcomes after cardiac arrest: a systematic review and meta-analysis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Pooled it
- Hemoglobin as a prognostic marker for neurological outcomes in post-cardiac arrest patients: a meta-analysis.Scientific reports · 2023Pooled it
- Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review.Intensive care medicine · 2022Pooled it
- Imaging for Neuroprognostication After Cardiac Arrest: Systematic Review and Meta-analysis.Neurocritical care · 2020Pooled it
- Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study.Scientific reports · 2021Trial
- Hounsfield unit and gray-white matter ratio estimates in pediatric normal controls used in studies evaluating head computed tomography.Neuroimage. Reports · 2026Article
- Gray-white matter ratio in pediatric and adult cardiopulmonary arrest studies: a rapid review.Resuscitation plus · 2026Review
- Correlation of Gray-to-White matter ratio on Non-Contrast CT with neurological outcome in Post-Cardiac arrest syndrome.BMJ neurology open · 2026Article
- Automated detection of severe cerebral edema using explainable deep transfer learning after hypoxic ischemic brain injury.Resuscitation · 2025Article
- Radiomics for Predicting the Development of Brain Edema from Normal-Appearing Early Brain-CT After Cardiac Arrest and Return of Spontaneous Circulation.Diagnostics (Basel, Switzerland) · 2025Article
- A predictive model for intracranial hemorrhage in adult patients receiving extracorporeal membrane oxygenation.World journal of emergency medicine · 2025Article
- Standardised and automated assessment of head computed tomography reliably predicts poor functional outcome after cardiac arrest: a prospective multicentre study.Intensive care medicine · 2024Observational
- Quantitative analysis of apparent diffusion coefficients to predict neurological prognosis in cardiac arrest survivors: an observational derivation and internal-external validation study.Critical care (London, England) · 2024Observational
- Outcome prediction of cardiac arrest with automatically computed gray-white matter ratio on computed tomography images.Critical care (London, England) · 2024Article
- Spontaneous Hypothermia As an Indicator of Early Diffuse Anoxic Brain Injury in Post-Cardiac Arrest Patients.Critical care explorations · 2024Article
- Review
- Deep learning-enabled detection of hypoxic-ischemic encephalopathy after cardiac arrest in CT scans: a comparative study of 2D and 3D approaches.Frontiers in neuroscience · 2024Article
- Both decreased and increased grey-to-white matter attenuation ratio in the putamen and caudate on early head computed tomography differentiate patients with favorable and unfavorable outcomes after prolonged cardiac arrest-secondary analysis of the Prague OHCA study.Quantitative imaging in medicine and surgery · 2023Article
- Prognostic accuracy of head computed tomography for prediction of functional outcome after out-of-hospital cardiac arrest: Rationale and design of the prospective TTM2-CT-substudy.Resuscitation plus · 2022Article
- Optic Nerve Sheath Diameter for Predicting Outcomes in Post-Cardiac Arrest Syndrome: An Updated Systematic Review and Meta-Analysis.Journal of personalized medicine · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMild therapeutic hypothermia alters the validity of a number of parameters currently used to predict neurological outcome after cardiac arrest and resuscitation. Thus, additional parameters are needed to increase certainty of early prognosis in these patients. A promising new approach is the determination of the gray-white-matter ratio (GWR) in cranial computed tomography (CCT) obtained early after resuscitation. It is not known how GWR relates to established outcome parameters such as neuron specific enolase (NSE) or somatosensory evoked potentials (SSEP).
methodsCardiac arrest patients (n = 98) treated with hypothermia were retrospectively analyzed with respect to the prognostic value of GWR, NSE and SSEP.
resultsA GWR < 1.16 predicted poor outcome with 100% specificity and 38% sensitivity. In 62 patients NSE, SSEP and CCT were available. The sensitivity of poor outcome prediction by both NSE > 97 μg/L and bilateral absent SSEP was 43%. The sensitivity increased to 53% in a multi-parameter approach predicting poor outcome using at least two of the three parameters (GWR, NSE and SSEP).
conclusionOur results suggest a strong association of a low GWR with poor outcome following cardiac arrest. Determination of the GWR increases the sensitivity in a multi-parameter approach for prediction of poor outcome after cardiac arrest.
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