ArticleThe journal of headache and pain2013
Genetic variants in the NOTCH4 gene influence the clinical features of migraine.
Article in The journal of headache and pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A study of differential microRNA expression profile in migraine: the microMIG exploratory study.The journal of headache and pain · 2023Article
- Genetic Variants Associated With Subjective Cognitive Decline in Patients With Migraine.Frontiers in aging neuroscience · 2022Article
- Identification of genetic risk loci for depression and migraine comorbidity in Han Chinese residing in Taiwan.Frontiers in psychiatry · 2022Article
- Article
- NOTCH4 is a possible novel susceptibility gene for dilated cardiomyopathy in the Chinese population: A case-control study.Journal of clinical laboratory analysis · 2018Article
- An Investigation of the Relationship between the eNOS Gene Polymorphism and Diagnosed Migraine.Balkan journal of medical genetics : BJMG · 2014Article
- Notch1 single nucleotide polymorphism rs3124591 is associated with the risk of development of invasive ductal breast carcinoma in a Chinese population.International journal of clinical and experimental pathology · 2014Article
- Genes and primary headaches: discovering new potential therapeutic targets.The journal of headache and pain · 2013Review
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11 authors.
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Abstract
backgroundRecent studies suggested an important role for vascular factors in migraine etiopathogenesis. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The aim of this study was to test the hypothesis that polymorphisms of the NOTCH4 gene would modify the occurrence and the clinical features of migraine.
findingsUsing a case-control strategy, we genotyped 239 migraine patients and 264 controls for three different non-synonymous polymorphisms (T320A, G835V, R1346P) of the NOTCH4 gene and for the (CTG) n-encoding polyleucine polymorphism in exon 1. Although the analyzed polymorphisms resulted not associated with migraine, the clinical characteristics of our patients were significantly influenced by the different NOTCH4 genotypes. Longer duration of disease and severity of neurovegetative symptoms during headache attacks were associated with the R1346P and G835V polymorphisms, respectively. In female patients, worsening of migraine symptoms at menarche was significantly correlated with T320A polymorphism.
conclusionsOur study shows that genetic variations within the NOTCH4 gene significantly modify the clinical characteristics of migraine and may have a role in disease pathogenesis.
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